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Life Sciences - Animal Sciences | Untranslated Gene Regions and Other Non-coding Elements - Regulation of Eukaryotic Gene Expression

Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression

Barrett, Lucy W., Fletcher, Sue, Wilton, Steve D.

2013, VIII, 56 p. 2 illus. in color.

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  • About this book

  • Revisits the idea of "junk" genetic material
  • Easy to read, concise overview of a complex subject
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Content Level » Research

Keywords » DNA regulation - Gene expression - Introns - Junk DNA - Non-coding RNA - Promotors

Related subjects » Animal Sciences - Human Genetics - Plant Sciences

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