Neural Cell Specification

1. Front Matter

   Pages i-xiii

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2. Pattern Formation in the Vertebrate CNS

   1. Front Matter

      Pages 1-1

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   2. Hox Gene Function and the Development of the Head

      • M. Mark, F. M. Rijli, T. Lufkin, P. Dollé, P. Gorry, P. Chambon

      Pages 3-16

   3. Genetic Mechanisms Responsible for Pattern Formation in the Vertebrate Hindbrain: Regulation of Hoxb-1

      • Michèle Studer, Heather Marshall, Heike Pöpperl, Atsushi Kuroiwa, Robb Krumlauf

      Pages 17-28

   4. Pax Genes as Pleiotropic Regulators of Embryonic Development

      • Patrick Tremblay, Susanne Dietrich, Anastasia Stoykova, Edward T. Stuart, Peter Gruss

      Pages 29-50

   5. Induction and the Generation of Regional and Cellular Diversity in the Developing Mammalian Brain

      • Anthony-Samuel LaMantia, Melissa C. Colbert, Elwood Linney

      Pages 51-65

3. Genetic Determinants of Neural Cell Fate

   1. Front Matter

      Pages 67-67

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   2. Potential Role of Homeobox Genes in Neural Cell Differentiation

      • Massimo Gulisano, Vania Broccoli, Fabio Spada, Edoardo Boncinelli

      Pages 69-84

   3. POU Domain Transcription Factors in the Neuroendocrine System

      • Bogi Andersen, Linda Erkman, Peng Li, Chijen R. Lin, Sheng-Cai Lin, Robert McEvilly et al.

      Pages 85-95

   4. Multiple Roles for Proneural Genes in Drosophila Neurogenesis

      • Andrew P. Jarman, Yuh Nung Jan

      Pages 97-104

   5. Genetic Analysis of Neuronal Migration in the Nematode Caenorhabditis elegans

      • Gian Garriga

      Pages 105-110

   6. Induction and Differentiation of Motor Neurons

      • S. L. Pfaff, T. Yamada, T. Edlund, T. M. Jessell

      Pages 111-124

4. Neural Cell Differentiation

   1. Front Matter

      Pages 125-125

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   2. Neuronal Development in the Rat Sympathoadrenal Lineage

      • S. J. Birren, J. M. Verdi, D. J. Anderson

      Pages 127-138

   3. Specification of Cell Fate in the Vertebrate Retina

      • C. P. Austin, C. L. Cepko

      Pages 139-143

   4. Neurotrophins and TRK Receptors in Hippocampal Development

      • Diana Collazo, Ron McKay

      Pages 145-170

   5. From Precursor Cell Biology to Tissue Repair in the O-2A Lineage

      • Andrew K. Groves, Mark Noble

      Pages 171-184

   6. Neuronal Cell Specification from CNS Stem Cells

      • S. Weiss, S. Ahmed, A. Vescovi, B. A. Reynolds

      Pages 185-188

   7. Community Living in Forebrain: Neural Precursors Modify Their Regional Specificity after Heterotopic Transplantation in the Telencephalon

      • Gordon J. Fishell

      Pages 189-194

   8. Targeted Neocortical Cell Death Guides the Fate of Transplanted Neural Precursors

      • Jeffrey D. Macklis

      Pages 195-207

The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.

• Embryo
• Enten
• Mammalia
• Nervous System
• development
• genes
• migration
• molecular mechanisms
• regulation

`An excellent summary for neurobiologists interested in neural development and regeneration and a starting point for researchers interested in entering the areas.'
Journal of Chemical

• University of Saskatchewan, Saskatoon, Canada

  J. Ronald Doucette

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