The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesis, for its biological similarities to the human will permit key discoveries. Mutagenesis of the Mouse Genome focuses on articles relevant to mouse chemical mutagenesis, and is dedicated to the memory of the mutagenesis pioneer, William L. Russell. Monica Justice provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. With special articles by Jean-Louis Guenet describing the history and development of mouse chemical mutagenesis, Liane Russell analyzing decades of data on DNA damage after chemical treatment, Steven Barthold describing how environment can affect mouse phenotypes, Miriam Meisler summarizing the power of allelic series, Molly Bogue describing the variation in mouse inbred strains, and Mark Strivens and Janan Eppig showing how informatics tools can aid in functional analysis, this book is designed to be a handbook and reference guide for mouse genetics in the post-genome era.
Foreword; M. Justice From the Atomic Age to the Genome Project; M.J. Justice Chemical mutagenesis of the mouse genome: an overview; J.-L. Guénet Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse; L.B. Russell Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions; M.H. Meisler, N.W. Plummer, D.L, Burgess, D.A. Buchner, L.K. Sprunger Towards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disorders; S. Rastan, T. Hough, A. Kierman, A. Erven, I.C. Gray, S. Voeling, A. Isaacs, H. Tsai, M. Strivens, R. Washbourne, C. Thornton, S. Greenaway, M. Hewitt, S. McCormick, R. Selley, C. Wells, Z. Tymowska-Lalanne, P. Roby, P. Mburu, D. Rogers, D. Kelsell, J.-L. Guénet, K.P. Steel, S. Sheardown, N. Spurr, I. Gray, J. Peters, P.M. Nolan, A.J. Hunter, S.D.M. Brown Implementing large-scale ENU mutagenesis screens in North America; A.T. Clark, D. Goldowitz, J.S. Takashi, M.H., Viterna, S.M. Siepka, L.L. Peters, W.N. Frankel, G.A. Carlson, J. Rossant, J.H. Nadeau, M.J. Justice Genetic mapping and ENU mutagenesis; D.R. Beier, B.J. Herron The Mouse Phenome Project; M.A. Bogue, S.C. Grubb Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes; S.W. Barthold Visualizing the laboratory mouse: capturing phenotype information; M. Strivens, J.T. Eppig