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Systems Biology

The Challenge of Complexity

  • Conference proceedings
  • © 2009

Overview

Editors:
  1. Shigetada Nakanishi

    1. Osaka Bioscience Institute, Osaka, Japan

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  2. Ryoichiro Kageyama

    1. Institute for Virus Research, Kyoto University, Kyoto, Japan

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  3. Dai Watanabe

    1. Department of Biological Sciences Faculty of Medicine, and Department of Molecular and System Biology, Graduate School of Biostudies Kyoto University, Kyoto, Japan

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About this book

Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.

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Table of contents (25 papers)

  1. Front Matter

    Pages i-xv
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  2. Dynamics and Complexity of Intercellular Networks

    1. Integrative Synaptic Mechanisms of the Neural Network

      • Shigetada Nakanishi
      Pages 3-10

    2. The Molecular and Cellular Design of Networks in Motion

      • Sten Grillner, Peter Wallén, Russell Hill
      Pages 11-23

    3. Bacterial Complexity: More Is Different on All Levels

      • Eshel Ben-Jacob
      Pages 25-35

    4. How Animals Get Their Skin Patterns: Fish Pigment Pattern as a Live Turing Wave

      • Shigeru Kondo
      Pages 37-46

    5. Characterization and Application of Natural Light-Sensitive Proteins

      • Jens Looser, Georg Nagel
      Pages 47-56

    6. Systems Biology of Mammalian Circadian Clocks

      • Hiroki R. Ueda
      Pages 57-69

    7. Toward Understanding How the Immune System Establishes a Diverse Yet Self-Tolerant T-Cell Repertoire: Stepwise Roles of Thymic Microenvironments

      • Takeshi Nitta, Yousuke Takahama
      Pages 71-82

    8. The Mechanisms of Motor Programming for Learned Vocalization in Songbirds

      • Hisataka Fujimoto, Hasegawa Taku, Ryosuke Matsui, Kentaro Abe, Watanabe Dai
      Pages 83-89

    9. Dynamic Model of the Basal Ganglia Functions and Movement Disorders

      • Atsushi Nambu
      Pages 91-97

  3. Integrative Mechanism of Intracellular Information Networks

    1. A Posttranslational Chemical Circadian Oscillator in Cyanobacteria

      • Hideo Iwasaki
      Pages 101-110

    2. The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways in an Early Analog and Late Digital Manner

      • Kevin A. Janes, H. Christian Reinhardt, Michael B. Yaffe
      Pages 111-120

    3. Specific Features of Transient Ras and Sustained Rap1 Activation

      • Yu-ichi Ozaki, Shinsuke Uda, Shinya Kuroda
      Pages 121-127

    4. Control and Alteration of Protein Traffic in the Cell

      • Toshiya Endo
      Pages 129-134

    5. Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Systems Biology

      • Kazuki Saito
      Pages 135-142

    6. A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealed by Pharmacokinetic Modeling

      • Naoki Watanabe, Chiharu Higashida
      Pages 143-149

    7. Molecules, Networks, and Memory

      • Upinder S. Bhalla
      Pages 151-158

    8. Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Network in Cerebellar Long-Term Synaptic Depression

      • Keiko Tanaka, George J. Augustine
      Pages 159-168

    9. Computational Models of Cerebellar Long-Term Memory

      • Hideaki Ogasawara, Mitsuo Kawato
      Pages 169-181

    10. Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressors

      • Soken Tsuchiya, Kazuya Terasawa, Ryo Kunimoto, Yasushi Okuno, Fumiaki Sato, Kazuharu Shimizu et al.
      Pages 183-189
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Editors and Affiliations

  • Osaka Bioscience Institute, Osaka, Japan

    Shigetada Nakanishi

  • Institute for Virus Research, Kyoto University, Kyoto, Japan

    Ryoichiro Kageyama

  • Department of Biological Sciences Faculty of Medicine, and Department of Molecular and System Biology, Graduate School of Biostudies Kyoto University, Kyoto, Japan

    Dai Watanabe

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