Overview
- Presents various stimuli introduction methods, including
- electroporation, microinjection, mechanoporation, optoporation
- or photoporation in
- Covers different fluidic systems and their integration with sensor technology, optical and hydrodynamic stretcher etc.
- Demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems
- Includes supplementary material: sn.pub/extras
Part of the book series: Series in BioEngineering (SERBIOENG)
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Table of contents (15 chapters)
Keywords
About this book
This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations.
This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis.
Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan.
Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.
Editors and Affiliations
About the editors
Dr. Fan-Gang Tseng received his Ph.D. degree in mechanical engineering from UCLA, USA, in 1998. He is currently a Distinguished Professor in the ESS Department as well as at the NEMS Institute, and the Deputy Director of the Biomedical Technology Research Center at NTHU. He is also an affiliated Research Fellow of Academia Sinica, Taiwan. He was elected as an ASME fellow in 2014. His research interests are in the fields of BioNEMS, Biosensors, Micro-Fluidics, Tissue Chips, and Fuel Cells. He holds 60 patents, authored 8 book chapters, and published more than 220 journal papers and 360 conference papers. Dr. Tseng currently serves on the editorial boards of Applied Sciences, Journal of Circuits and Systems, International Journal of Molecule Science, Micromachines, and Open Nanomedicine Journal. He received many awards, including National Innovation Award (twice), Outstanding Research Award (MOST and NSC, twice), First-Class Research Award (NSC), Mr. Wu, Da-Yo Memorial Award (NSC), NTHU Outstanding Research Award (2005-2015), and more than twelve best paper/poster awards from various competitions and conferences.
Dr. Tuhin Subhra Santra received his Ph.D. degree in Bio-Nano Electro Mechanical Systems (Bio-NEMS) from the Institute of Nanoengineering and Microsystems (NEMS), National Tsing Hua University (NTHU), Taiwan in 2013. Currently he is a Postdoctoral Research Associate at the California Nano System Institute (CNSI), University of California, Los Angeles (UCLA), USA. His main research areas are Bio-NEMS, MEMS, Single-Cell Analysis, Bio-micro/nano Fabrication, Biomedical Microdevices, Nanomedicine and etc. Dr. Santra serves as a Guest Editor for the Journal of Micromachines, Journal of Molecules, International Journal of Molecular Science, Sensors and Transducers Journal, American Journal of Nanoresearch and Application, among others. Dr. Santra has received many awards such as the NTHU Outstanding Student Award in 2011 and 2013, IEEE-NEMSBest Conference Paper Award in 2014, Best Poster Award at 15th Nano/Microsystem Conference in 2012, Junior Research Fellowship from the IIT-Kharagpur in 2008, Outstanding Student Award from the Jadavpur University in 2005 and 2006, Silver Medal from the Vidyasagar University in 2004. Dr. Santra has published more than 15 international journal papers, six book chapters, 31 international conference papers in his research field. He also has one US and one Taiwan patent pending.
Bibliographic Information
Book Title: Essentials of Single-Cell Analysis
Book Subtitle: Concepts, Applications and Future Prospects
Editors: Fan-Gang Tseng, Tuhin Subhra Santra
Series Title: Series in BioEngineering
DOI: https://doi.org/10.1007/978-3-662-49118-8
Publisher: Springer Berlin, Heidelberg
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2016
Hardcover ISBN: 978-3-662-49116-4Published: 10 February 2016
Softcover ISBN: 978-3-662-56980-1Published: 30 March 2018
eBook ISBN: 978-3-662-49118-8Published: 21 January 2016
Series ISSN: 2196-8861
Series E-ISSN: 2196-887X
Edition Number: 1
Number of Pages: X, 414
Number of Illustrations: 127 b/w illustrations, 15 illustrations in colour
Topics: Biomedical Engineering and Bioengineering, Microengineering, Bioinformatics, Biological and Medical Physics, Biophysics, Cell Biology