Self-Assembling Peptide Systems in Biology, Medicine and Engineering

1. Front Matter

   Pages i-xii

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2. Exploiting Peptide Self-assembly to Engineer Novel Biopolymers: Tapes, Ribbons, Fibrils and Fibres

   • A. Aggeli, I. A. Nyrkova, M. Bell, L. Carrick, T. C. B. Mcleish, A. N. Semenov et al.

   Pages 1-17

3. Ribbon-Like Lamellar Structures from Chain-Folded Polypeptides

   • E. D. T. Atkins

   Pages 19-33

4. Design of Self-Assembling Peptides as Catalyst Mimetics Using Synthetic Combinatorial Libraries

   • S. E. Blondelle, E. Crooks, N. Reixach, E. Pérez-Payá

   Pages 35-45

5. Thermodynamics of Protein-Protein and Peptide Interactions

   • Alan Cooper

   Pages 47-64

6. The Mechanism of Amyloid Formation and Its Links to Human Disease and Biological Evolution

   • Christopher M. Dobson

   Pages 65-74

7. Transgenic Plants for Large Scale Production of Peptides and Proteins

   • Klaus Düring

   Pages 15-85

8. Assembly Modulation of Channel-Forming Peptides

   • S. Futaki

   Pages 87-104

9. Molecular Casting of Infectious Amyloids, Inorganic and Organic Replication: Nucleation, Conformational Change and Self-Assembly

   • D. C. Gajdusek

   Pages 105-112

10. Structure and Stabilisation of Self-Assembling Peptide Filaments

    • Nicholas J. Gay, Martyn Symmons, Marisa Martin-Fernandez, Gareth Jones

    Pages 113-125

11. Designed Combinatorial Libraries of Novel Amyloid-Like Proteins

    • M.H. Hecht, M.W. Rest, J. Patterson, J.D. Mancias, J.R. Beasley, B.M. Broome et al.

    Pages 127-138

12. Design of Synthetic Branched Chain Polymeric Polypeptides for Targeting/Delivering Bioactive Molecules

    • F. Hudecz

    Pages 139-160

13. Amyloid-Like Fibrils from a Peptide-Analogue of the Central Domain of Silkmoth Chorion Proteins

    • Vassiliki A. Conomidou, Stavros J. Hamodrankas

    Pages 161-169

14. Amyloidogenesis of Islet Amyloid Polypeptide (IAPP)

    • A. Kapurniotu

    Pages 171-185

15. Engineering Self-Assembly of Peptides by Amphiphilic 2D Motifs: α-to-β Transitions of Peptides

    • H. Mihara, Y. Takahashi, I. Obataya, S. Sakamoto

    Pages 187-205

16. Model Signal Peptides: Probes of Molecular Interactions During Protein Secretion

    • A. Miller, L. Wang, D. A. Kendall

    Pages 207-220

17. Structure, Folding and Assembly of Adenovirus Fibers

    • Anna Mitraki, Mark Van Raaij, Rob Ruigrok, Stephen Cusack, Jean-Francois Hernandez, Mary Luckey

    Pages 221-234

18. Solving the Structure of Collagen

    • A. Rich

    Pages 235-241

19. Disulfide Bond Based Self-Assembly of Peptides Leading To Spheroidal Cyclic Trimers

    • Miriam Royo, Miquel Àngel Contreras, Juan Cebrián, Ernest Giralt, Fernando Albericio, Miquel Pons

    Pages 243-256

20. A New Circular Helicoid-Type Sequential Oligopeptide carrier for Assembling Multiple Antigenic Peptides

    • Marta Sakarellos-Daitsiotis, Vassilios Tsikaris, Constantinos Sakarellos

    Pages 257-271

One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.

• Biopolymer
• Lipid
• Tissue Engineering
• biomedical engineering
• membrane proteins
• polymer
• proteins
• thermodynamics

• University of Leeds, UK

  Amalia Aggeli, Neville Boden

• Massachusetts Institute of Technology, Cambridge, USA

  Shuguang Zhang

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