Neuroepigenomics in Aging and Disease
Editors: Delgado-Morales, Raul (Ed.)
- One of the first books covering the major epigenetic changes on brain disorders throughout the entire lifespan of the patients
- An invaluable reference that supplies extensive coverage of the role of all the principal epigenetic modifications in brain disorders.
- First volume to include specific scientific knowledge on neuroepigenomics, including informative summaries that will help everyone from researchers to non-scientists to understand the complexity of the human brain
Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).
The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.
Raúl Delgado-Morales holds a PhD in Neuroscience. He completed his doctoral studies at the Universitat Autònoma de Barcelona working on the field of epigenetics on depression. He continued his research as a postdoc at the Max Planck Institute of Psychiatry in Munich. Dr. Delgado-Morales currently works as a postdoctoral researcher at the Bellvitge Biomedical Research Institute (IDIBELL), in Barcelona, Spain in the field of neuroepigenomics.
Table of contents (25 chapters)
MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome
The Role of Noncoding RNAs in Neurodevelopmental Disorders: The Case of Rett Syndrome
Rubinstein-Taybi Syndrome and Epigenetic Alterations
Epigenetics of Autism Spectrum Disorder
Eating Disorders and Epigenetics
- Bibliographic Information
- Book Title
- Neuroepigenomics in Aging and Disease
- Raul Delgado-Morales
- Series Title
- Proteomics, Metabolomics, Interactomics and Systems Biology
- Series Volume
- Springer International Publishing
- Copyright Holder
- Springer International Publishing AG
- イーブック ISBN
- ハードカバー ISBN
- Edition Number
- Number of Pages
- XIII, 525
- Number of Illustrations and Tables
- 2 b/w illustrations, 39 illustrations in colour