Drug Delivery and Translational Research - Featured Article: February 2024
Read the featured article from the February 2024 issue! (this opens in a new tab)
Pulmonary delivery of mRNA via inhalation is a very attractive approach for RNA-based therapy for treatment of lung diseases. In this work, using spray drying technique, we have demonstrated successful development of a dry powder formulation of mRNA-lipid nanoparticles (LNPs), with mannitol and leucine as excipients. The desired critical attributes for the dry powder form were accomplished by optimization of numerous parameters. Intratracheal administration of this dosage form show successful delivery of functional mRNA. Our results show successful mRNA delivery with a dry powder formulation of mRNA LNPs, underscoring the great potential of this dosage form for future development of mRNA therapeutics for lung diseases.
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