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Patient-Derived Xenograft Models of Human Cancer

  • Book
  • © 2017

Overview

Editors:
  1. Yuzhuo Wang

    1. Department of Urologic Sciences, University of British Columbia, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Dong Lin

    1. Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Peter W. Gout

    1. Living Tumor Laboratory, BC Cancer Agency/Vancouver Prostate Centre, Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive, state-of-the art review of PDX cancer models
  • Written by world-renowned experts in the field
  • Provides interactivity through extensive illustrations

Part of the book series: Molecular and Translational Medicine (MOLEMED)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xi
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  2. Patient-Derived Tumor Xenografts: Historical Background

    • Dong Lin, Xinya Wang, Peter W. Gout, Yuzhuo Wang
    Pages 1-9

  3. Towards Best Practice in Establishing Patient-Derived Xenografts

    • Gail P. Risbridger, Mitchell G. Lawrence
    Pages 11-28

  4. Fidelity and Stability of PDX Models

    • Gang Li
    Pages 29-42

  5. Humanized Mouse and Rat PDX Cancer Models

    • Fallon K. Noto, Tseten Yeshi
    Pages 43-57

  6. Studies of Cancer Heterogeneity Using PDX Models

    • Danyi Wen, Feifei Zhang, Yuan Long
    Pages 59-69

  7. The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts

    • Alastair H. Davies, Fraser Johnson, Kirsi Ketola, Amina Zoubeidi
    Pages 71-91

  8. Modeling Cancer Metastasis

    • Nora M. Navone, Estefania Labanca
    Pages 93-114

  9. Modeling Drug Resistance in PDX Models

    • Erin L. Stewart, Ming Sound Tsao
    Pages 115-126

  10. Using PDX for Biomarker Development

    • Werner J. Struss, Peter C. Black
    Pages 127-140

  11. Patient-Derived Xenografts as Cancer Models for Preclinical Drug Screening

    • Juliet A. Williams
    Pages 141-154

  12. First-Generation Tumor Xenografts: A Link Between Patient-Derived Xenograft Models and Clinical Disease

    • Xin Dong, Peter W. Gout, Lu Yi, Yinhuai Wang, Yong Xu, Kuo Yang
    Pages 155-176

  13. Application of PDX Cancer Models in Co-clinical Trials and Personalized/Precision Medicine

    • Hongwei Cheng, Zongwen Liu, Hui Xue, Peter W. Gout, Hong Shan
    Pages 177-192

  14. Prospectives

    • Dong Lin, Yuzhuo Wang, Peter W. Gout
    Pages 193-200

  15. Back Matter

    Pages 201-204
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Keywords

About this book

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. 


Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the currentstatus of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.


Editors and Affiliations

  • Department of Urologic Sciences, University of British Columbia, Vancouver, Canada

    Yuzhuo Wang

  • Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada

    Dong Lin

  • Living Tumor Laboratory, BC Cancer Agency/Vancouver Prostate Centre, Vancouver, Canada

    Peter W. Gout

About the editors

Yuzhuo Wang, PhD
Director, Living Tumor Laboratory
Distinguished Scientist, BC Cancer Agency
Senior Scientist, Vancouver Prostate Centre
Professor, University of British Columbia
675 West 10th Avenue, Room 3.122
Vancouver, BC, Canada V5Z 1L3




Dong Lin, PhD, MD
Research Pathologist, Living Tumor Laboratory

Peter W. Gout, PhD
Scientific Consultant, Living Tumor Laboratory
Honorary Associate Professor, Department of Urologic Sciences, University of British Columbia
Emeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency
<675 West 10th Avenue, Room 5.108Vancouver, BC, Canada V5Z 1L3





Bibliographic Information

  • Book Title: Patient-Derived Xenograft Models of Human Cancer

  • Editors: Yuzhuo Wang, Dong Lin, Peter W. Gout

  • Series Title: Molecular and Translational Medicine

  • DOI: https://doi.org/10.1007/978-3-319-55825-7

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-55824-0Published: 21 July 2017

  • Softcover ISBN: 978-3-319-85758-9Published: 12 June 2018

  • eBook ISBN: 978-3-319-55825-7Published: 27 June 2017

  • Series ISSN: 2197-7852

  • Series E-ISSN: 2197-7860

  • Edition Number: 1

  • Number of Pages: XI, 204

  • Number of Illustrations: 1 b/w illustrations, 26 illustrations in colour

  • Topics: Oncology

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