Fundamentals of Evidence-Based Health Care and Translational Science

1. Front Matter

   Pages i-xxvii

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2. Fundamental Implications for Clinical Practice

   1. Front Matter

      Pages 1-1

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   2. Translational Effectiveness in the Context of Translational Science

      • Francesco Chiappelli

      Pages 3-31

   3. Comparative Effectiveness Analysis and Evidence-Based Decisions

      • Francesco Chiappelli

      Pages 33-64

   4. Methodology I: The Best Available Evidence

      • Francesco Chiappelli

      Pages 65-88

   5. Methodology II: Sampling and Assessment of the Evidence

      • Francesco Chiappelli

      Pages 89-119

   6. Methodology III: Systematic Evaluation of the Statistical Analysis: Data Analysis in Research Synthesis

      • Francesco Chiappelli

      Pages 121-154

3. Optimizing Clinical Practice-Based Patient-Centered Outcomes Research

   1. Front Matter

      Pages 155-155

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   2. Getting and Understanding Data

      • Francesco Chiappelli

      Pages 157-199

   3. Obtaining Data

      • Francesco Chiappelli

      Pages 201-228

   4. Describing and Analyzing Data

      • Francesco Chiappelli

      Pages 229-267

   5. Translational Effectiveness Analysis

      • Francesco Chiappelli

      Pages 269-290

   6. Optimizing Clinical Outcomes by Individualizing Observations

      • Francesco Chiappelli

      Pages 291-309

   7. Evaluation in Patient-Centered Outcomes Research

      • Francesco Chiappelli

      Pages 311-323

   8. Translational Effectiveness in Practice-Based Patient-Centered Outcomes Research

      • Francesco Chiappelli

      Pages 325-359

4. Back Matter

   Pages 361-394

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Comparative effectiveness research – the conduct and synthesis of systematic research in order to compare the benefits and harms of alternative treatment options – is of critical importance in enabling informed health care decisions to be made. This user-friendly, practical handbook examines in depth how best to perform such comparative effectiveness research. A wide range of topics and methods are discussed, including research synthesis, sampling analysis, assessment of evidence design, systematic evaluation of statistical analysis, and meta-analysis. The discussion extends well beyond the fundamentals by encompassing “complex” systematic reviews, “cumulative” meta-analyses, and logic-based versus utility-based decision making. Health care providers, researchers, instructors, and students will all find this to be an invaluable reference on the compelling current issues and important analytical tools in comparative effectiveness research.

• level of evidence
• meta-analysis
• research synthesis
• systematic review

From the book reviews:

“This is a single-author reference on evidence-based practice and translational science by a well-recognized author in the field. … The intended audience includes clinical investigators, medical practitioners, and students and teachers in medical sciences (especially dentistry), clinical/basic research, statistics, epidemiology, and biostatistics. … This book is excellent. It is a valuable resource for gaining a basic understanding of evidence-based research and translational science and its practical application … .” (Bhavesh Barad, Doody’s Book Reviews, September, 2014)

• CHS 63-090, UCLA School of Dentistry, Los Angeles, USA

  Francesco Chiappelli

Professor Francesco Chiappelli, Ph.D. has contributed extensively to the development of the field of evidence-based and comparative effectiveness decision-making in health care over the past several years through his teaching, research publications, and authorship of several book chapters and books. Professor Chiappelli is the founder and director of the International Forum on evidence-based decisions and comparative effectiveness research (IF-EBD-CER), and is the honorary president of the Brazilian Association for Evidence-based dentistry. He is a American Dental Association Champion of evidence-based dentistry, and he is listed as a Fulbright Specialists for his expertise in evidence-based and comparative effectiveness analysis in health care.

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