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Cell Division Machinery and Disease

  • Book
  • © 2017

Overview

Editors:
  1. Monica Gotta

    1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Patrick Meraldi

    1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Reviews the current knowledge to critically evaluate the causal link between cell division machinery and disease
  • Identifies key open questions in the field and means for exploring them
  • Explores cell division and links to common disorders including cancer, aging and infertility

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1002)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Meiotic Divisions: No Place for Gender Equality

    • Warif El Yakoubi, Katja Wassmann
    Pages 1-17

  3. Consequences of Centrosome Dysfunction During Brain Development

    • Maddalena Nano, Renata Basto
    Pages 19-45

  4. Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells

    • Alexander D. Rhys, Susana A. Godinho
    Pages 47-67

  5. Kinetochore Malfunction in Human Pathologies

    • Bas de Wolf, Geert J. P. L. Kops
    Pages 69-91

  6. The Elephant in the Room: The Role of Microtubules in Cancer

    • Luca Cirillo, Monica Gotta, Patrick Meraldi
    Pages 93-124

  7. Clinical Development of Anti-mitotic Drugs in Cancer

    • Anna-Maria Olziersky, S. Intidhar Labidi-Galy
    Pages 125-152

  8. Mitotic Dysfunction Associated with Aging Hallmarks

    • Joana Catarina Macedo, Sara Vaz, Elsa Logarinho
    Pages 153-188

  9. Unbalanced Growth, Senescence and Aging

    • Michael Polymenis, Brian K. Kennedy
    Pages 189-208

  10. The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization

    • Abigail L. D. Tadenev, Basile Tarchini
    Pages 209-225

  11. Back Matter

    Pages 227-235
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Keywords

About this book

This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Editors and Affiliations

  • Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Monica Gotta, Patrick Meraldi

About the editors

Monica Gotta is Ordinary Professor at the Medical Faculty of the University of Geneva. She has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. Her research interests are the (a)symmetric cell divisions of C. elegans embryos and human cells. She has published 43 papers and 1 book chapter. She has also been awarded an EMBO YIP award.

Patrick Meraldi is Associate Professor at the Medical Faculty of the University of Geneva. He has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. His research interest is primarily in the field of chromosome segregation in human cells. He has published 49 papers and 2 book chapters. He has also been awarded an EURYI award , an EMBO YIP award and the Walther Flemming Medal. 

Bibliographic Information

  • Book Title: Cell Division Machinery and Disease

  • Editors: Monica Gotta, Patrick Meraldi

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-57127-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-57125-6Published: 21 June 2017

  • Softcover ISBN: 978-3-319-86083-1Published: 02 August 2018

  • eBook ISBN: 978-3-319-57127-0Published: 09 June 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 235

  • Number of Illustrations: 1 b/w illustrations, 32 illustrations in colour

  • Topics: Cell Cycle Analysis, Cell Physiology, Cancer Research

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