Directed Enzyme Evolution: Advances and Applications

Editors: Alcalde, Miguel (Ed.)

  • Offers a comprehensive view on directed evolution in the biotechnological ground
  • Presents a state of the art summary of the methodical advances in this thrilling research field Highlights the most significant applications of engineered enzymes in industry
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eBook 130,89 €
price for India (gross)
  • ISBN 978-3-319-50413-1
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  • Immediate eBook download after purchase
Hardcover 156,99 €
price for India (gross)
  • ISBN 978-3-319-50411-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art.

Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature.

The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection.

About the authors

Prof. Dr. Miguel Alcalde Institute of Catalysis, CSIC Campus Cantoblanco 28049 Madrid Spain Tel: +34 91 5854760 E-mail: malcalde@icp.csic.es

Table of contents (10 chapters)

  • Directed Evolution of an Allosteric Tryptophan Synthase to Create a Platform for Synthesis of Noncanonical Amino Acids

    Murciano-Calles, Javier (et al.)

    Pages 1-16

    Preview Buy Chapter 24,95 €
  • Engineering Therapeutic Enzymes

    Lutz, Stefan (et al.)

    Pages 17-67

    Preview Buy Chapter 24,95 €
  • Recent Advances in Directed Evolution of Stereoselective Enzymes

    Reetz, Manfred T.

    Pages 69-99

    Preview Buy Chapter 24,95 €
  • Improving CO2 Fixation by Enhancing Rubisco Performance

    Wilson, Robert H. (et al.)

    Pages 101-126

    Preview Buy Chapter 24,95 €
  • Directed Evolution of Unspecific Peroxygenase

    Molina-Espeja, Patricia (et al.)

    Pages 127-143

    Preview Buy Chapter 24,95 €

Buy this book

eBook 130,89 €
price for India (gross)
  • ISBN 978-3-319-50413-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 156,99 €
price for India (gross)
  • ISBN 978-3-319-50411-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Directed Enzyme Evolution: Advances and Applications
Editors
  • Miguel Alcalde
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-50413-1
DOI
10.1007/978-3-319-50413-1
Hardcover ISBN
978-3-319-50411-7
Edition Number
1
Number of Pages
VII, 284
Number of Illustrations and Tables
36 b/w illustrations, 26 illustrations in colour
Topics