Leukemia and Lymphoma

1. Front Matter

   Pages i-xii

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2. Flow-Cytometry Methods for the Detection of Residual Leukemia

   • Richard Ratei, Wolf-Dieter Ludwig

   Pages 1-19

3. Flow-Cytometry—Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic Leukemia

   • Dario Campana

   Pages 21-36

4. PCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

   • Geoffrey Neale

   Pages 37-51

5. Statistical Considerations in the Analysis of Minimal Residual Disease

   • Dennis A. Johnston, Theodore F. Zipf

   Pages 53-75

6. The Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making Process

   • Theodore F. Zipf, Dennis A. Johnston

   Pages 77-83

7. Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for Acute Lymphoblastic Leukemia

   • John Moppett, Amos Burke, Christopher Knechtli, Anthony Oakhill, Colin Steward, Nicholas J. Goulden

   Pages 85-96

8. Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage

   • Letizia Foroni, Forida Y. Mortuza, A. Victor Hoffbrand

   Pages 97-117

9. Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping

   • Jesús F. San Miguel, María B. Vidriales, Alberto Orfao

   Pages 119-136

10. Minimal Residual Disease in Acute Myeloid Leukemia

    • Guido Marcucci, Michael A. Caligiuri

    Pages 137-161

11. Minimal Residual Disease in Acute Promyelocytic Leukemia

    • Francesco Lo Coco, Daniela Diverio

    Pages 163-178

12. Minimal Residual Disease in Chronic Myelogenous Leukemia

    • Nicholas C. P. Cross, Andreas Hochhaus

    Pages 179-199

13. Utility of PCR Assessment of Minimal Residual Disease After Stem Cell Transplantation in Non-Hodgkin’s Lymphoma

    • Angela M. Krackhardt, John G. Gribben

    Pages 201-222

14. Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18)

    • Apostolia-Marie Tsimberidou, Yunfang Jiang, Richard J. Ford, Fernando Cabanillas, Andreas H. Sarris

    Pages 223-236

15. Monitoring Follicular Lymphoma by Polymerase Chain Reaction

    • Ming-Sheng Lee, Fernando Cabanillas

    Pages 237-242

16. Editors’ Notes

    • Theodore F. Zipf, Dennis A. Johnston

    Pages 243-248

17. Back Matter

    Pages 249-257

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In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.

• DNA
• cell
• clinical trial
• leukemia
• lymphoma
• stem cell
• stem cell transplantation
• transplantation

"The book provides an excellent presentation of a wide spectrum of methods used in detection of MRD in ALL, CML, AML and Hodgkins lymphoma. It will certainly be of great help for all those, who are engaged in modern management of leukemias and lymphomas." -Neoplasma

• Houston, USA

  Theodore F. Zipf

• Department of Biomathematics, MD Anderson Cancer Center, Houston, USA

  Dennis A. Johnston

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