Overview
- Editors:
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Edgar Jacoby
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Basel, Switzerland
- Provides an easily accessible reference volume for chemogenomic approaches written by leading researchers in the field
- Details in silico and in vitro processes for target and hit finding
- Covers a wide range of chemogenomic concepts and their applications
- Presents integrative approach to chemistry, biology, and molecular informatics components defining chemogenomics
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Table of contents (13 protocols)
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- K. V. Balakin, Y. A. Ivanenkov, N. P. Savchuk
Pages 21-46
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- Jeremy M. Murray, Dirksen E. Bussiere
Pages 47-92
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- Ratna Singh, Andrea Mozzarelli
Pages 93-122
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- Garland R. Marshall, Daniel J. Kuster, Ye Che
Pages 123-158
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- Sarma A. R. P. Jagarlapudi, K. V. Radha Kishan
Pages 159-172
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- Edgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen et al.
Pages 173-194
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- Michael J. Keiser, Jérôme Hert
Pages 195-205
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- Josef Scheiber, Jeremy L. Jenkins
Pages 207-223
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- Richard J. Brennan, Tatiana Nikolskya, Svetlana Bureeva
Pages 225-247
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- Ruben Abagyan, Irina Kufareva
Pages 249-279
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- Ulrich Schopfer, Caroline Engeloch, Frank Höhn, Hervé Mees, Jennifer Leeds, Fraser Glickman et al.
Pages 297-316
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Back Matter
Pages 317-320
About this book
Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment, analysis, prediction, and expansion of a comprehensive ligand–target SAR (structure–activity relationship) matrix has followed the elucidation of the human genome and presents a key scientific challenge for the twenty-first century. The anno- tion and knowledge-based exploration of the ligand–target SAR matrix is then expected to impact science greatly. Progress alongside this challenge without a doubt will c- tribute to further the fundamental understanding of the biological function of the individual proteins and ultimately provide a basis for the discovery of new and better therapies for diseases. While historically the chemogenomics approach is based on efforts that systematically explore target gene families, today broader in vitro and in silico approaches are available to encompass wider genomes. In this book, experts from academia and industry outline relevant aspects of ch- istry, biology, and molecular informatics which are the cornerstones of chemogenomics. General introductory chapters are combined with chapters describing methods and pro- cols, which are the gold standard of the Methods in Molecular Biology book series.
Reviews
From the reviews:
“Provide practical and authoritative reviews on current research topics. … The present book represents an illustrative compendium of up-to-date chemogenomics, with a strong emphasis on bio- and cheminformatic concepts. … It therefore represents a valuable complement to published books that are more ‘chemical biology’ driven. It is of particular interest for the ‘data miners’ of the chemogenomics community, giving them an authoritative overview of current technologies and methods available throughout industry and academia.” (Markus Kaiser, ChemBioChem, Vol. 11, March, 2010)
Editors and Affiliations
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Basel, Switzerland
Edgar Jacoby
