Overview
Reviews key mechanisms underlying the link between obesity and cancer
Explores the role of various signaling pathways in the development of obesity-associated cancer
Presents drugs and therapeutic agents targeting obesity-induced cancer
Discusses the role of genetic factors in obesity-associated cancer
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents(16 chapters)
Keywords
About this book
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers.
The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.
Editors and Affiliations
-
Department of Biochemistry, Central University of Punjab, Bathinda, India
Shashank Kumar
-
Department of Urology, Case Western Reserve University, Cleveland, USA
Sanjay Gupta
About the editors
Dr. Shashank Kumar is working as Assistant Professor at the Department of Biochemistry, Central University of Punjab, Punjab, India. He has been alumni of the Department of Biochemistry, King George’s Medical University, and the Department of Biochemistry, University of Allahabad, India. Dr. Kumar edited many books including, Concepts in Cell Signaling, Secondary Metabolites and Functional Food Components, and Carbohydrate Metabolism Theory and Practical Approach, Phytochemistry: An in silico and in vitro updates, etc. Dr. Shashank’s basic research focuses on understanding the role of miRNAs in breast cancer pathophysiology and developing appropriate biomarkers for early detection and prognosis of the disease. The translational research focus is to identify novel synthetic and natural inhibitors of signaling pathways related to disease pathophysiology. Dr. Kumar has more than 50 published scientific papers/reviews/editorial articles in various National/International peer-reviewed journals of repute. He has been a member of various national/international academic bodies.
Prof. Sanjay Gupta is a Professor & Research Director and holds Carter Kissell Endowed Chair in Urologic Oncology in the Department of Urology at Case Western Reserve University and The Urology Institute at the University Hospitals Case Medical Center. He also holds secondary appointments in the Departments of Nutrition and Division of General Medical Sciences at Case Comprehensive Cancer Center. Dr. Gupta has a joint appointment as Research Scientist at the Louis Stokes VA Medical Center, Cleveland, Ohio. Dr. Gupta has authored some 150 publications, including book chapters, research articles and reviews, and has spoken on several occasions in cancer prevention symposiums, seminars, and meetings. He has been serving in various study sections at National Cancer Institute (NCI) and Department of Defense (DOD), and other councils worldwide. He also serves on the Editorial Board as well as a reviewer for several prestigious scientific journals.
Bibliographic Information
Book Title: Obesity and Cancer
Editors: Shashank Kumar, Sanjay Gupta
DOI: https://doi.org/10.1007/978-981-16-1846-8
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
Hardcover ISBN: 978-981-16-1845-1Published: 20 July 2021
Softcover ISBN: 978-981-16-1848-2Published: 21 July 2022
eBook ISBN: 978-981-16-1846-8Published: 18 July 2021
Edition Number: 1
Number of Pages: IX, 361
Number of Illustrations: 15 b/w illustrations, 23 illustrations in colour
Topics: Cancer Research, Medicine/Public Health, general, Immunology, Bioinformatics