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Uremic Toxins and Organ Failure

  • Book
  • © 2020

Overview

Editors:
  1. Hideyuki Saito

    1. Department of Pharmacy, Kumamoto University Hospital, Kumamoto University, Kumamoto, Japan

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  2. Takaaki Abe

    1. Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides detailed descriptions of toxico-pathological mechanisms

  • Presents the latest research on the gut-kidney axis

  • Describes a new therapeutic strategy for CKD

  • Includes special chapters in indoxyl sulfate, ADMA, Sulfotransferase 1A1, and D-serine

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Overview of Uremic Toxins

    • Toshimitsu Niwa
    Pages 1-15

  3. Review: Uremic Toxins and Gut Microbiome

    • Takehiro Suzuki, Takaaki Abe
    Pages 17-39

  4. Gut Microbiota and Systemic Uremic Solute Accumulation

    • Eikan Mishima
    Pages 41-51

  5. Uremic Toxin-Related Systemic Disorders

    • Suguru Yamamoto
    Pages 53-67

  6. Uremic Toxins and Cardiovascular Disease

    • Toyoaki Murohara
    Pages 69-81

  7. Indoxyl Sulfate and Arteriosclerosis

    • Toshiaki Nakano
    Pages 83-93

  8. Uremic Toxicity and Bone in CKD

    • Yoshiko Iwasaki, Hideyuki Yamato, Masafumi Fukagawa
    Pages 95-114

  9. D-serine as a Novel Uremic Toxin

    • Haruki Ouchi, Yosuke Hirakawa, Reiko Inagi
    Pages 115-129

  10. Uremic Solutes and Sarcopenia

    • Hiroshi Watanabe, Hiromasa Kato, Yuki Enoki, Hitoshi Maeda, Toru Maruyama
    Pages 131-147

  11. Toxico-Pathological Role of Hepatic Sulfotransferase (SULT) 1A1 in Acute Kidney Injuries

    • Hideyuki Saito
    Pages 149-166

  12. Accumulation of Uremic Toxins in Systemic Organs and the Effect of AST-120

    • Emiko Sato
    Pages 167-180
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Keywords

About this book

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

Editors and Affiliations

  • Department of Pharmacy, Kumamoto University Hospital, Kumamoto University, Kumamoto, Japan

    Hideyuki Saito

  • Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Takaaki Abe

About the editors

Hideyuki Saito

Department of Pharmacy, Kumamoto University Hospital & Department of Clinical Pharmaceutical Sciences, Kumamoto University Graduate School of Life Sciences, Kumamoto University

Honjo, Chuo-ku, Kumamoto, Japan

Email: saitohide@kuh.kumamoto-u.ac.jp

 

Takaaki Abe

Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine

Tohoku University Graduate School of Medicine

Seiryo-cho, Aoba-ku, Sendai, Japan

Email: takaabe@med.tohoku.ac.jp


Bibliographic Information

  • Book Title: Uremic Toxins and Organ Failure

  • Editors: Hideyuki Saito, Takaaki Abe

  • DOI: https://doi.org/10.1007/978-981-15-7793-2

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2020

  • Hardcover ISBN: 978-981-15-7792-5Published: 13 October 2020

  • Softcover ISBN: 978-981-15-7795-6Published: 14 October 2021

  • eBook ISBN: 978-981-15-7793-2Published: 12 October 2020

  • Edition Number: 1

  • Number of Pages: VIII, 180

  • Number of Illustrations: 17 b/w illustrations, 22 illustrations in colour

  • Topics: Nephrology, Gastroenterology, Cardiology

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