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Role of Exosomes in Biological Communication Systems

  • Book
  • © 2021

Overview

Editors:
  1. Faisal A. Alzahrani

    1. Department of Biochemistry, ESC Research Unit, Faculty of Science King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

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  2. Islam M. Saadeldin

    1. Department of Animal Production, King Saud University, Riyadh, Saudi Arabia

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    You can also search for this editor in PubMed   Google Scholar

  • Summarizes the isolation, structural and functional role of exosomes in normal physiology

  • Examines the role of exosomes in pathophysiological conditions

  • Explores the potential of exosomes in therapeutic and regenerative medicine

  • Reviews the use of exosomal microRNA as tumor biomarkers

  • Presents natural and synthetic exosomes used for drug delivery

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
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  2. Isolation and Characterization of Extracellular Vesicles: Classical and Modern Approaches

    • Ahmed E. Noreldin, Asmaa F. Khafaga, Rasha A. Barakat
    Pages 1-25

  3. Characterization and Fine Structure of Exosomes

    • Fawzia A. Al-shubaily, Maryam H. Al-Zahrani
    Pages 27-75

  4. Extracellular Vesicles Mediate the Embryonic-Maternal Paracrine Communication

    • Islam M. Saadeldin
    Pages 77-97

  5. The Interplay Between Oviduct-Derived Exosomes and Cumulus-Oocyte Complexes

    • Seok Hee Lee, Byeong Chun Lee
    Pages 99-113

  6. The Interplay Between Exosomes and Spermatozoa

    • Ahmad Yar Qamar, Xun Fang, Seonggyu Bang, Feriel Yasmine Mahiddine, Min Jung Kim, Jongki Cho
    Pages 115-139

  7. Mesenchymal Stem Cell–Derived Exosomes and Regenerative Medicine

    • Hoda Elkhenany, Shilpi Gupta
    Pages 141-164

  8. Therapeutic Potential of Mesenchymal Stem/Stromal Cell–Derived Exosomes

    • Fawaz Abomaray
    Pages 165-181

  9. Exosomes in Neurodegenerative Disorders

    • Ahmed Osama Elmehrath, Yousef Tarek Sonbol, Moaz Yahia Farghal
    Pages 183-206

  10. Differential Expression of Exosomal MicroRNAs in Neurodegenerative Diseases

    • Nesma Elsayed Abdelaal, Mostafa Fathi Abdelhai
    Pages 207-219

  11. Urinary Exosomes as a Possible Source of Kidney Disease Biomarkers

    • Ahmed Abdeen, Hiroko Sonoda, Ayae Tanaka, Masahiro Ikeda
    Pages 221-244

  12. Extracellular Vesicles as Potential Therapeutic Targets and Biomarkers for Liver Disease

    • Faisal Abdulrahman Alzahrani
    Pages 245-260

  13. Implications of Extracellular Vesicles in Blood Protozoan Parasitic Diseases

    • Nagham Gamal Masoud, Nagwa Mostafa El-Sayed, Manar Ezz Elarab Ramadan
    Pages 261-276

  14. Cancer Cells–Derived Exosomes and Metastasis

    • Wahaj Alnefaie
    Pages 277-292

  15. Extracellular Vesicles and Integrins: Partners in Cancer Progression

    • Wanessa Fernanda Altei, Bianca Cruz Pachane, Patty Karina dos Santos, Heloisa Sobreiro Selistre de Araújo
    Pages 293-310

  16. Exosomes: The Crucial Element in Prostate Cancer

    • Mohammed Moulay, Saleh Al-Kareem
    Pages 311-319

  17. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response and Prognosis

    • Faizah Alotaibi
    Pages 321-336

  18. Exosomes in Drug Delivery

    • Fahad A. Almughem, Abdullah A. Alshehri, Mohammad N. Alomary
    Pages 337-360

  19. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems

    • Mahmoud A. Elnaggar, Yoon Ki Joung
    Pages 361-373
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Keywords

About this book

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.


Editors and Affiliations

  • Department of Biochemistry, ESC Research Unit, Faculty of Science King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Faisal A. Alzahrani

  • Department of Animal Production, King Saud University, Riyadh, Saudi Arabia

    Islam M. Saadeldin

About the editors

Dr. Faisal A. Alzahrani is an Associate Professor of Molecular Biology at King Abdulaziz University. He received his Ph.D. in Medical Sciences from North West Cancer Research Centre at Bangor University, where he studied the mechanisms of genome maintenance in cancer stem cells and stem cells. After that, he joined the university as a faculty member, set up his team and laboratory, and was appointed as deputy head of the stem cell unit. Dr. Alzahrani subsequently focused his research on stem cell-derived exosomes and their therapeutic applications. While working as a visiting lecturer at Aston Medical School in the UK, he became more interested in translating research and joined MirZyme Therapeutics as Vice President for the MENA region.


Dr. Islam M. Saadeldin is an Associate Professor at King Saud University, Saudi Arabia and adjunct Associate Professor at Zagazig University, Egypt. He obtained his Ph.D. from Seoul National University, South Korea in 2012. He was a visiting scholar at Niigata University, Japan (2008), and also served as a postdoctoral fellow at Seoul National University (2013-2014). He received the Asian Universities Alliance (AUA) Scholar Award in 2019 and a visiting professorship to Seoul National University. He holds a patent for embryo transgenesis through PiggyBac transposons. He has published more than 100 research articles on animal cloning, genome editing, assisted reproductive techniques, adult and embryonic stem cells, as well as the roles of exosomes in pathophysiology and embryonic-maternal crosstalk, in respected journals.  He also serves on the editorial boards of Frontiers in Veterinary Science, Journal of Animal Reproduction ad Biotechnology, and Cloning and Transgenesis, and as an associate editor for The Open Stem Cell Journal.



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