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In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

  • Describes two major in vivo inhalation-toxicity screening methods: the short-term inhalation study (STIS) and intratracheal administration
  • Collects up-to-date information on test procedures and interpretation of the results, useful applications and related technologies for each inhalation toxicity screening method
  • Provides a pragmatic reference resource for those responsible for safety assessments of nanomaterials in R&D and business, as well as researchers

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
  2. The Role of In Vivo Screening Studies in Assessing Manufactured Nanomaterials

    • Robert Landsiedel, Masashi Gamo, Akihiko Hirose
    Pages 1-21
  3. Intratracheal Administration Study

    1. Front Matter

      Pages 93-93
    2. Comparison of Responses in Rat Lung Following Inhalation and Intratracheal Administration of Nanoparticles

      • Yukiko Yoshiura, Yuri Fujisawa, Taisuke Tomonaga, Hiroto Izumi, Takako Oyabu, Toshihiko Myojo et al.
      Pages 95-105
    3. Standardization of Intratracheal Instillation Study of Manufactured Nanomaterials

      • Toshio Kobayashi, Yutaka Oshima, Yasuhiro Tsubokura, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka et al.
      Pages 107-122
    4. Sample Preparation and the Characterization for Intratracheal Administration

      • Kenji Kawaguchi, Kenji Koga, Takeshi Sasaki
      Pages 123-144
    5. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study Using Intratracheal Administration

      • Yutaka Oshima, Toshio Kobayashi, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka
      Pages 165-192

About this book

This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials.

With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.


Editors and Affiliations

  • Graduate School of Health Management, Keio University, Fujisawa, Japan

    Toru Takebayashi

  • Experimental Toxicology and Ecology, BASF SE, Ludwigshafen am Rhein, Germany

    Robert Landsiedel

  • National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

    Masashi Gamo

About the editors

Toru Takebayashi
Keio University
Graduate School of Health Management
Fujisawa, Kanagawa, Japan

Robert Landsiedel
BASF SE
Experimental Toxicology and Ecology
Ludwigshafen am Rhein, Germany


Masashi Gamo
National Institute of Advanced Industrial Science and Technology (AIST)
Tsukuba, Ibaraki, Japan


Bibliographic Information

  • Book Title: In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

  • Editors: Toru Takebayashi, Robert Landsiedel, Masashi Gamo

  • Series Title: Current Topics in Environmental Health and Preventive Medicine

  • DOI: https://doi.org/10.1007/978-981-13-8433-2

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-8432-5Published: 03 September 2019

  • Softcover ISBN: 978-981-13-8435-6Published: 03 September 2020

  • eBook ISBN: 978-981-13-8433-2Published: 20 August 2019

  • Series ISSN: 2364-8333

  • Series E-ISSN: 2364-8341

  • Edition Number: 1

  • Number of Pages: VI, 223

  • Number of Illustrations: 8 b/w illustrations, 62 illustrations in colour

  • Topics: Health Promotion and Disease Prevention, Health Administration, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access