Hematological Disorders in Children

1. Front Matter

   Pages i-x

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2. Hematopoiesis

   1. Front Matter

      Pages 1-1

      PDF

   2. Hematopoietic Stem Cells: The Basis of Normal and Malignant Hematopoiesis

      • Mariko Eguchi, Minenori Eguchi-Ishimae, Eiichi Ishii

      Pages 3-29

3. White Blood Cell Disorders

   1. Front Matter

      Pages 31-31

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   2. Acute Lymphoblastic Leukemia

      • Daisuke Tomizawa, Nobutaka Kiyokawa

      Pages 33-60

   3. Acute Myeloid Leukemia

      • Souichi Adachi, Akitoshi Kinoshita, Daisuke Tomizawa, Takashi Taga, Hiroyuki Takahashi

      Pages 61-85

   4. Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)

      • Daisuke Hasegawa, Atsushi Manabe

      Pages 87-108

   5. Neutropenia (In Infancy and Childhood)

      • Masao Kobayashi, Yoko Mizoguchi, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi

      Pages 109-113

4. Red Blood Cell Disorders

   1. Front Matter

      Pages 115-115

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   2. Childhood Aplastic Anemia

      • Hiroshi Yagasaki

      Pages 117-144

   3. Inherited Bone Marrow Failure Syndrome, TAM

      • Etsuro Ito, Kiminori Terui, Tsutomu Toki

      Pages 145-170

5. Platelet and Coagulation Disorders

   1. Front Matter

      Pages 171-171

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   2. Immune and Inherited Thrombocytopenia in Children

      • Masue Imaizumi

      Pages 173-187

   3. Pathogenesis and Treatment of Hemophilia

      • Keiji Nogami, Midori Shima

      Pages 189-204

   4. Thrombotic Disorders

      • Shouichi Ohga, Masataka Ishimura

      Pages 205-221

6. Histiocytic Disorders

   1. Front Matter

      Pages 223-223

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   2. Langerhans Cell Histiocytosis

      • Akira Morimoto

      Pages 225-246

   3. Primary Hemophagocytic Lymphohistiocytosis

      • Takahiro Yasumi, Hirofumi Shibata, Saeko Shimodera, Toshio Heike

      Pages 247-261

   4. Hemophagocytic Lymphohistiocytosis, Secondary

      • Ryu Yanagisawa, Yozo Nakazawa

      Pages 263-269

This book describes the pathogenesis and treatment of several representative hematological disorders in children, with a special focus on genetic and molecular aspects. Research on the pathogenesis of hematological disorders in children has made remarkable strides; especially molecular target therapy has shown outstanding effects in refractory and conventional therapies for childhood leukemia. The findings presented in this book will broaden readers’ understanding and hopefully spark new discussions leading to the development of new therapies including cell therapy and molecular target therapy, allowing clinicians to use more effective and less toxic approaches in the future.
Hematological Disorders in Children will appeal to a wide readership, from medical students and beginning investigators to experienced scholars in the field of pediatric hematology and oncology seeking to broaden their understanding and keep up with the latest developments. It will also be of interest to the parents of pediatric patients, and to co-medical staffs.

• Childhood
• Infant
• Molecular Target Therapy
• Anemia
• Leukemia
• Hemophilia
• Thrombosis
• LCH

“This unique treatise describes the pathogenesis and treatment modalities of childhood hematologic disorders that are both currently in use and that show future promise. ... The intended audience includes not only medical specialists who are involved in treating pediatric patients, but also medical students, research scientists, and even parents of afflicted children who can gain some perspective on the complexities of these disorders and the progress being made to treat them.” (Ravi Salgia, Doody's Book Reviews, April, 2018)



“A concise treatise which in 3 chapters divided into 3 parts summarizes present knowledge on hematological diseases in childhood. With illustrations, tables and many references. For pediatricians in practice and in training.” (Pediatric Endocrinology Reviews, Vol. 15 (2), December, 2017)

• Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan

  Eiichi Ishii

Editor: Dr Eiichi Ishii, Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan

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