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Sirtuins

  • Book
  • © 2016

Overview

Editors:
  1. Riekelt H. Houtkooper

    1. Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands

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  • Key leaders in the field of sirtuin biology share their expertise
  • Covers a wide variety of physiological processes controlled by sirtuin proteins
  • Offers new insights into how sirtuin proteins can be targeted to treat age-related diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Proteins and Cell Regulation (PROR, volume 10)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Biochemistry and Enzymology of Sirtuins

    • Yue Yang, Anthony A. Sauve
    Pages 1-27

  3. NAD+ as a Pharmacological Tool to Boost Sirtuin Activity

    • Riekelt H. Houtkooper
    Pages 29-40

  4. Protein Lysine Acylation: Abundance, Dynamics and Function

    • Olga Pougovkina, Vincent C. J. de Boer
    Pages 41-69

  5. SIRT1 in Metabolic Health and Disease

    • Marie Boutant, Carles Cantó
    Pages 71-104

  6. Deacetylation by SIRT3 Relieves Inhibition of Mitochondrial Protein Function

    • Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell et al.
    Pages 105-138

  7. SIRT5 Reveals Novel Enzymatic Activities of Sirtuins

    • Bin He, Hening Lin
    Pages 139-147

  8. Diverse Roles for SIRT6 in Mammalian Healthspan and Longevity

    • Bernadette M. M. Zwaans, William Giblin, David B. Lombard
    Pages 149-170

  9. Sirtuins in Cancer – Emerging Role as Modulators of Metabolic Reprogramming

    • Jaewon J. Lee, Karina N. Gonzalez Herrera, Marcia C. Haigis
    Pages 171-190

  10. Sirtuins as Metabolic Modulators of Muscle Plasticity

    • Keir Menzies, Julien Francisco Zaldivar-Jolissaint, Johan Auwerx
    Pages 191-211

  11. Sirtuins and Aging

    • Carles Cantó, Riekelt H. Houtkooper
    Pages 213-227

  12. Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk

    • Selma Masri, Marina Maria Bellet, Paolo Sassone-Corsi
    Pages 229-242

  13. Sirtuin Activation by Small Molecules

    • Hassina Massudi, Lindsay E. Wu, David A. Sinclair
    Pages 243-266

  14. Sirtuins: A Future Perspective

    • Brian K. Kennedy
    Pages 267-273

  15. Back Matter

    Pages 275-288
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Keywords

About this book

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Editors and Affiliations

  • Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands

    Riekelt H. Houtkooper

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