Editors:
- Covering a variety of complementary experimental technologies
- Providing an up-to-date overview of structure based drug discovery and development
- Describing macromolecule-centred and ligand-centred techniques
- Presenting topics of interest to a wide audience, including structural biologists, computational chemists, and medicinal chemists
- Includes supplementary material: sn.pub/extras
Part of the book series: NATO Science for Peace and Security Series A: Chemistry and Biology (NAPSA)
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Table of contents (17 papers)
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Front Matter
About this book
The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.
Editors and Affiliations
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Structural Chemistry Department, Merck & Co, Inc., Kenilworth, USA
Giovanna Scapin
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Center for Advanced Biotechnology and Medicine, and Rutgers University, Piscataway, USA
Disha Patel, Eddy Arnold
Bibliographic Information
Book Title: Multifaceted Roles of Crystallography in Modern Drug Discovery
Editors: Giovanna Scapin, Disha Patel, Eddy Arnold
Series Title: NATO Science for Peace and Security Series A: Chemistry and Biology
DOI: https://doi.org/10.1007/978-94-017-9719-1
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2015
Hardcover ISBN: 978-94-017-9718-4Published: 12 March 2015
Softcover ISBN: 978-94-017-9724-5Published: 12 March 2015
eBook ISBN: 978-94-017-9719-1Published: 27 February 2015
Series ISSN: 1874-6489
Series E-ISSN: 1874-6527
Edition Number: 1
Number of Pages: XI, 240
Number of Illustrations: 18 b/w illustrations, 89 illustrations in colour
Topics: Protein-Ligand Interactions, Medicinal Chemistry, Molecular Medicine, Theoretical and Computational Chemistry, Crystallography and Scattering Methods