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AIDS Pathogenesis

  • Book
  • © 2000

Overview

Editors:
  1. Hanneke Schuitemaker

    1. CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands

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  2. Frank Miedema

    1. CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Immunology and Medicine (IMME, volume 28)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XI
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  2. HIV-1 Transmission

    • Angélique Van’t Wout, Richard A. Koup, William A. Paxton
    Pages 1-17

  3. Primary HIV Infection

    • Andrew Carr, David A. Cooper
    Pages 19-40

  4. Biological Variability of HIV-1

    • Jan Albert, Maarten Koot
    Pages 41-54

  5. T-Cell Dynamics and Renewal in HIV-1 Infection

    • Dawn R. Clark, Katja C. Wolthers
    Pages 55-64

  6. Long-Term Non-Progressive HIV Infection

    • Susan Buchbinder, Eric Vittinghoff
    Pages 65-75

  7. Cytotoxic T Lymphocytes in HIV-1 Infection

    • M. R. Klein, S. H. Van der Burg, B. Autran
    Pages 77-98

  8. Mechanisms and in-vivo Significance of HIV-1 Neutralisation

    • Paul W. H. I. Parren, Dennis R. Burton, Quentin J. Sattentau
    Pages 99-132

  9. Suppression of Primate Immunodeficiency Lentiretroviruses by CD8+ T-Cell-Derived Soluble Factors

    • Paolo Lusso
    Pages 133-153

  10. Opportunistic Infections

    • Jannik Helweg-Larsen, Thomas L. Benfield, Jens D. Lundgren
    Pages 155-176

  11. A — Aids-Related Non-Hodgkin’s Lymphomas

    • Marie José Kersten, M. H. J. Van Oers
    Pages 177-194

  12. B — Pathogenesis of Kaposi’s Sarcoma

    • Thomas F. Schulz
    Pages 195-208

  13. Aids Dementia Complex

    • Peter Portegies, Roelien H. Enting
    Pages 209-220

  14. Anti-Retroviral Therapy and Resistance to Anti-Retroviral Drugs

    • Joep M. A. Lange, Julio S. G. Montaner
    Pages 221-242

  15. Prognostic Markers and Immunological Reconstitution During HIV-1 Infection

    • Marijke Th. L. Roos, Nadine G. Pakker, Peter Th. A. Schellekens
    Pages 243-259

  16. HIV Viral Load

    • Frank De Wolf, Ingrid Spijkerman
    Pages 261-272

  17. A — The SCID-hu Mouse: An in-vivo Model for HIV-1 Infection in Humans

    • Hideto Kaneshima
    Pages 273-278

  18. B — Non-Human Primate Models for HIV-1 Infection

    • Norman L. Letvin
    Pages 279-282

  19. Back Matter

    Pages 283-283
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Keywords

About this book

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS).
The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Editors and Affiliations

  • CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands

    Hanneke Schuitemaker, Frank Miedema

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