Mechanisms of Carcinogenesis

1. Front Matter

   Pages i-x

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2. The Influence of Human Behavior on Neoplastic Progression

   • H. E. Kaiser

   Pages 1-6

3. The Influence of Stressors on the Progression of Neoplastic Change

   • Hymie Anisman, Jill Irwin, Lawrence S. Sklar

   Pages 7-18

4. The Seven Types of Causes of Neoplastic Growth — An Organismic View

   • H. E. Kaiser

   Pages 19-30

5. Chemoprevention Research

   • Winfred F. Malone

   Pages 31-42

6. Premalignant and Non-Invasive Lesions of the Urinary Bladder

   • Sonny L. Johansson, Samuel M. Cohen

   Pages 43-50

7. Species-Specific Aspects of the Carcinogenicity of Chloroform

   • Elizabeth K. Weisburger

   Pages 51-53

8. Carcinogenic Effects of Ionizing Radiation

   • Arthur C. Upton

   Pages 54-70

9. Selected Aspects of Viral Carcinogenesis

   • Prem S. Sarin

   Pages 71-83

10. The Quantum Theory of Carcinogenesis — A Short Review

    • J. Ladik, P. Otto

    Pages 84-86

11. Cellular Oncogene Activation by Chromosomal Translocation

    • Ken R. Harewood

    Pages 87-91

12. Amplification of the Oncogene N-MFC as a Correlate to Advanced Stage in Human Neuroblastomas

    • Manfred Schwab

    Pages 92-97

13. Potential Roles of Activated Proto-Oncogenes in Malignant Progression

    • Gary E. Gallick

    Pages 98-105

14. Oncogenes and their Encoded Products as Targets for Cancer Therapy

    • Doris L. Slate

    Pages 106-112

15. Methods to Study Ras Oncogene-Mediated Induction of the Metastatic Phenotype

    • U. P. Thorgeirsson, T. Turpeenniemi-Hujanen, M. Ballin, L. A. Liotta

    Pages 113-118

16. Oncogene Products as Potential Therapeutic Targets for Control of Established Metastatic Disease

    • Ronald H. Goldfarb, Kenneth W. Brunson

    Pages 119-127

17. Neoplastic Cell Stages and Progression in Experimental Hepatocarcinogenesis

    • Ewalt Scherer

    Pages 128-144

18. Characterization of Eleven Important Transplantable Murine Tumors from the Standpoint of Morphology, Pyrimidine Biosynthesis and Responsiveness to Pyrimidine Antimetabolites

    • Thomas W. Kensler, Hildegard M. Schuller, Hiremagalur N. Jayaram, David A. Cooney

    Pages 145-156

19. Use of Organ Explant and Cell Culture in Cancer Research

    • James H. Resau, John R. Cottrell

    Pages 157-159

20. Season of Operation and Differential Long-Term Progression: Clinical, Statistical, and Psychological Issues

    • E. H. Krokowski, H. W. Wendt, P. A. Homyak

    Pages 160-168

but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non­ or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco­ bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe­ reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

• Mamma
• Tumor
• cancer
• carcinogenesis
• carcinoma
• cell
• cell culture
• metastatic disease
• oncogene
• prevention

• National Cancer Institute, National Institutes of Health, Bethesda, USA

  Elizabeth K. Weisburger

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