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Tight Junctions in Cancer Metastasis

  • Book
  • © 2013

Overview

Editors:
  1. Tracey A. Martin

    1. Cardiff University, Institute of Cancer & Genetics, Cardiff, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Wen G. Jiang

    1. Cardiff University, Institute of Cancer & Genetics, Cardiff, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First Tight Junction & Cancer Metastasis book
  • Information on a wide range of cancer types
  • Information of tight junction proteins
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Molecular Aspects of Tight Junctions

    • Elaine A. McSherry, Mark B. Owens, Ann M. Hopkins
    Pages 1-27

  3. The Distribution of Tight Junctions and Junctional Proteins in the Human Body

    • Anna-Maria Tokes, Zsuzsa Schaff, Attila Marcell Szasz, Janina Kulka
    Pages 29-64

  4. Methods to Study Tight Junctions

    • María Isabel Larre, Catalina Flores-Maldonado, Marcelino Cereijido
    Pages 65-80

  5. Enhanced Vascular Permeability in Solid Tumors: A Promise for Anticancer Nanomedicine

    • Sebastien Taurin, Khaled Greish
    Pages 81-118

  6. Tight Junctions, Junctional Adhesion Molecules (JAMs), and the Blood Brain Barrier

    • Klaus Ebnet, Benjamin F. Brinkmann, Daniel Kummer, Steve Misselwitz, Swetha S. D. Peddibhotla, Hüseyin Tuncay
    Pages 119-129

  7. Tight Junctions in Human Urinary Bladder Cancer

    • Tracey A. Martin, Mark Haynes, Ninaard Answare, Gareth Brown, Wen G. Jiang
    Pages 131-148

  8. Tight Junctions in Colorectal Cancer

    • Frédéric Hollande, Marina Papin
    Pages 149-167

  9. Tight Junctions in Breast Cancer: Multifaceted Players in Tumorigenesis and Progression

    • Yvonne Myal, Anne A. A. Blanchard
    Pages 169-196

  10. Regulation of Tight Junctions for Therapeutic Advantages

    • Lorenza González-Mariscal, Mónica Díaz-Coránguez, Miguel Quirós
    Pages 197-246

  11. VEGF-Mediated Effects on Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across the Blood-Brain Barrier

    • Shalom Avraham, Shuxian Jiang, Lili Wang, Yigong Fu, Hava Karsenty Avraham
    Pages 247-261

  12. Claudin-5 and Cancer Metastasis

    • Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Fernando Augusto Soares
    Pages 263-274

  13. Signaling Pathways Regulating Endothelial Cell-Cell Junctions as a Barrier to Tumor Cell Metastasis

    • Shigetomo Fukuhara, Naoki Mochizuki
    Pages 275-289

  14. The ROCK Signalling Pathway and Tight Junctions

    • Jane Lane, Tracey A. Martin, Wen G. Jiang
    Pages 291-301

  15. Back Matter

    Pages 303-313
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Keywords

About this book

There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Editors and Affiliations

  • Cardiff University, Institute of Cancer & Genetics, Cardiff, United Kingdom

    Tracey A. Martin, Wen G. Jiang

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