Islets of Langerhans

1. Front Matter

   Pages i-xxxi

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2. The Comparative Anatomy of Islets

   • R. Scott Heller

   Pages 1-18

3. Microscopic Anatomy of the Human Islet of Langerhans

   • Peter In’t Veld, Silke Smeets

   Pages 19-38

4. Basement Membrane in Pancreatic Islet Function

   • Eckhard Lammert, Martin Kragl

   Pages 39-58

5. Approaches for Imaging Pancreatic Islets: Recent Advances and Future Prospects

   • Xavier Montet, Smaragda Lamprianou, Laurent Vinet, Paolo Meda, Alfredo Fort

   Pages 59-81

6. Mouse Islet Isolation

   • Simona Marzorati, Miriam Ramirez-Dominguez

   Pages 83-107

7. Regulation of Pancreatic Islet Formation

   • Manuel Carrasco, Anabel Rojas, Irene Delgado, Nadia Cobo Vuilleumier, Juan R. Tejedo, Francisco J. Bedoya et al.

   Pages 109-128

8. (Dys)Regulation of Insulin Secretion by Macronutrients

   • Philip Newsholme, Kevin Keane, Celine Gaudel, Neville McClenaghan

   Pages 129-156

9. Physiology and Pathology of the Anomeric Specificity for the Glucose-Induced Secretory Response of Insulin-, Glucagon-, and Somatostatin-Producing Pancreatic Islet Cells

   • Willy J. Malaisse

   Pages 157-173

10. Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic α-Cells

    • Patrick Gilon, Rui Cheng-Xue, Bao Khanh Lai, Hee-Young Chae, Ana Gómez-Ruiz

    Pages 175-247

11. Electrophysiology of Islet Cells

    • Gisela Drews, Peter Krippeit-Drews, Martina Düfer

    Pages 249-303

12. ATP-Sensitive Potassium Channels in Health and Disease

    • Peter Proks, Rebecca Clark

    Pages 305-336

13. β Cell Store-Operated Ion Channels

    • Colin A. Leech, Richard F. Kopp, Louis H. Philipson, Michael W. Roe

    Pages 337-368

14. Anionic Transporters and Channels in Pancreatic Islet Cells

    • Nurdan Bulur, Willy J. Malaisse

    Pages 369-399

15. Chloride Channels and Transporters in β-Cell Physiology

    • Mauricio Di Fulvio, Peter D. Brown, Lydia Aguilar-Bryan

    Pages 401-451

16. Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets

    • Richard Bertram, Arthur Sherman, Leslie S. Satin

    Pages 453-474

17. Exocytosis in Islet β-Cells

    • Haruo Kasai, Hiroyasu Hatakeyama, Mitsuyo Ohno, Noriko Takahashi

    Pages 475-510

18. Zinc Transporters in the Endocrine Pancreas

    • Mariea Dencey Bosco, Chris Drogemuller, Peter Zalewski, Patrick Toby Coates

    Pages 511-527

19. High-Fat Programming of β-Cell Dysfunction

    • Marlon E. Cerf

    Pages 529-546

20. Exercise -Induced Pancreatic Islet Adaptations in Health and Disease

    • Sabrina Grassiolli, Antonio Carlos Boschero, Everardo Magalhães Carneiro, Cláudio Cesar Zoppi

    Pages 547-564

This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.

• Beta cells
• Diabetes
• Insulin
• Islet transplantation
• Islets

• Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

  Md. Shahidul Islam

Md. Shahidul Islam, M.D., Ph.D

Associate professor, group leader, department of clinical science and education, Karolinska Institutet, Stockholm, Sweden

Senior consultant physician, internal medicine, Uppsala university hospital, Uppsala, Sweden

Founder president of Islet Society

Editor-in-Chief, Islets

Editors of the islets of Langerhans, Transient receptor potential channels, calcium signaling

Recipient of career development award from the Juvenile Diabetes Research Foundation, International; Anders Fredrik Regnell´s award from the Swedish Society of Medicine; Chittagong Medical College golden jubilee award.

Specialist in internal medicine, certified by the National Board of Health and Welfare, Sweden

Ph.D. from Karolinska Institutet, Stockholm, Sweden

Medical graduate from the Chittagong Medical College, Bangladesh

Premedical from Faujdarhat Cadet College, Bangladesh

 

Research interest: study of signal transduction in the islet cells with a focus on the ion channels, and GPCRS, in the context of pathogenesis, and treatment of diabetes

Policies and ethics