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Antibody Expression and Production

  • Book
  • © 2011

Overview

Editors:
  1. Mohamed Al-Rubeai

    1. Dept. Chemical & Biochemical, Engineering, University College, Dublin, Belfield, Dublin 4, Ireland

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  • Detailed background for antibody generation and production
  • Chapters on production of antibody in bacterial, fungal, mammalian, insects and transgenic animal and plants
  • Scientific and technical approaches to accelerating the development of robust upstream and downstream processes
  • Identify the limitations in developing processes for antibody production

Part of the book series: Cell Engineering (CEEN, volume 7)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Expression of Antibody in Mammalian Cells

    • Thomas Jostock
    Pages 1-24

  3. Bioreactor Systems for Producing Antibody from Mammalian Cells

    • Darrin Kuystermans, Mohamed Al-Rubeai
    Pages 25-52

  4. Production of Antibody in Insect Cells

    • Hideki Yamaji
    Pages 53-76

  5. Production of Monoclonal Antibodies in Glycoengineered Pichia pastoris

    • Dongxing Zha, Thomas Linden, Thomas Potgieter
    Pages 77-98

  6. Production of Antibodies in Hansenula polymorpha

    • Georg Melmer, Stephan Hellwig, Grit Hehmann, Ulrike Dahlems
    Pages 99-119

  7. Production of Antibody by Transgenic Avians

    • Yoshinori Kawabe, Masamichi Kamihira
    Pages 121-141

  8. Production of Antibodies in Plants

    • Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell, Diego Orzaez
    Pages 143-164

  9. Production of Antibody Fab Fragments in Escherichia coli

    • Hiroshi Tachibana, Masataka Takekoshi
    Pages 165-178

  10. Intrabody Expression in Mammalian Cells

    • Silvia Biocca
    Pages 179-195

  11. Engineering Antibodies for Cancer Therapy

    • Lisa E. Goldsmith, Matthew K. Robinson
    Pages 197-233

  12. Recombinant Bispecific Antibodies for Cancer Therapy

    • Dafne Müller, Roland E. Kontermann
    Pages 235-249

  13. The Role of Glycosylation in Therapeutic Antibodies

    • Maureen Spearman, Ben Dionne, Michael Butler
    Pages 251-292

  14. Quality Issues Arising from Post-translational Modification of Recombinant Antibodies

    • Raymond Tyther, Nigel Jenkins
    Pages 293-303

  15. Recovery and Purification of Antibody

    • XueJun Han, Arthur Hewig, Ganesh Vedantham
    Pages 305-340

  16. Back Matter

    Pages 341-345
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Keywords

About this book

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

Editors and Affiliations

  • Dept. Chemical & Biochemical, Engineering, University College, Dublin, Belfield, Dublin 4, Ireland

    Mohamed Al-Rubeai

Bibliographic Information

  • Book Title: Antibody Expression and Production

  • Editors: Mohamed Al-Rubeai

  • Series Title: Cell Engineering

  • DOI: https://doi.org/10.1007/978-94-007-1257-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-94-007-1256-0Published: 18 May 2011

  • Softcover ISBN: 978-94-007-3613-9Published: 15 July 2013

  • eBook ISBN: 978-94-007-1257-7Published: 16 May 2011

  • Series ISSN: 1389-6946

  • Series E-ISSN: 2542-9515

  • Edition Number: 1

  • Number of Pages: X, 346

  • Topics: Biomedicine general

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