From Molecular to Modular Tumor Therapy:

1. Front Matter

   Pages i-viii

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2. Therapy-Derived Systems Biology: A Pragmatic Communication Theory

   1. Front Matter

      Pages 1-1

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   2. Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients

      • Albrecht Reichle

      Pages 3-7

   3. Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options

      • Albrecht Reichle

      Pages 9-28

   4. Principles of Modular Tumor Therapy

      • Albrecht Reichle, Gerhard C. Hildebrandt

      Pages 29-47

3. Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies

   1. Front Matter

      Pages 49-49

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   2. Cancer and Coagulation; Focusing on Tissue Factor and Heparanase

      • Yona Nadir

      Pages 51-74

   3. The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity

      • Ofer Shoshani, Dov Zipori

      Pages 75-96

   4. Shaping Tumor Associated Macrophages: The Role of NF-κB

      • Robin Soper, Thorsten Hagemann

      Pages 97-110

   5. The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target

      • Eva Gottfried, Katrin Peter, Marina P. Kreutz

      Pages 111-132

   6. Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?

      • Oliver Grauer, Peter Hau

      Pages 133-157

4. Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’

   1. Front Matter

      Pages 159-159

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   2. Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins

      • Wendy Wing Shan Yeung, Maurice Kwok Chung Ho, Yung Hou Wong

      Pages 161-189

   3. Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-κB

      • Ilse M. E. Beck, Guy Haegeman, Karolien De Bosscher

      Pages 191-242

   4. The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment

      • Urban Emmenegger, Annabelle Chow, Guido Bocci

      Pages 243-262

5. Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy

   1. Front Matter

      Pages 263-263

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   2. Systems Biology: A Therapeutic Target for Tumor Therapy

      • Albrecht Reichle, Thomas Vogt

      Pages 265-285

   3. The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation

      • Albrecht Reichle, Gerhard C. Hildebrandt

      Pages 287-303

   4. Searching for the ‘Metabolism’ of Evolution

      • Albrecht Reichle, Gerhard C. Hildebrand

      Pages 305-309

6. Biomodulatory Therapy Approaches in Metastatic Cancer

   1. Front Matter

      Pages 311-311

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The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away―in a scientifically accessible manner―from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: • First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, • then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and • finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions).

• Carcinom
• Communication theory (integration of communication)
• Evolution, modularity
• Holism-reductionism
• Tumor models
• Tumor-associated inflammation
• regulation

• , Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

  Albrecht Reichle

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