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Proteases in Gastrointestinal Tissues

  • Book
  • © 2006

Overview

Editors:
  1. Uwe Lendeckel

    1. Otto-von-Guericke University, Magdeburg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Nigel M. Hooper

    1. University of Leeds, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Devoted to proteases in liver, stomach, colon, pancreas specifically and extensively
  • Covers major diseases of gastrointestinal tissues
  • Introducing individual proteases (or families of) extensively
  • Up to date presentation of patient-derived and experimental data
  • Covers all aspects of protease function in disease, ranging from molecular mechanisms of pathogenesis, diagnostic value, and treatment options

Part of the book series: Proteases in Biology and Disease (PBAD, volume 5)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Protease-Activated Receptors in Gastrointestinal Function and Disease

    • Nigel W. Bunnett, Graeme S. Cottrell
    Pages 1-31

  3. Matrix Metalloproteinases in Gastric Cancer

    • Nikhil I. Khushalani, Nithya Ramnath
    Pages 33-60

  4. Proteases in Helicobacter pylori-Mediated Diseases

    • Thomas Wex, Michael Zack, Peter Malfertheiner
    Pages 61-87

  5. Proteases in Pancreatic Disease

    • Avinash Sewpaul, Jeremy J. French, Richard M. Charnley
    Pages 89-121

  6. PAR in the Pathogenesis of Pain in Pancreatic Disease

    • Pankaj J. Pasricha
    Pages 123-130

  7. Importance of the Local Renin-Angiotensin System in Pancreatic Disease

    • Po Sing Leung
    Pages 131-152

  8. Hepatitis C Viral Proteases And Inhibitors

    • Mingjun Huang, Avinash Phadke, Atul Agarwal
    Pages 153-181

  9. Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis

    • Yao Hong Wei
    Pages 183-207

  10. Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation

    • Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek
    Pages 209-234

  11. MMPs and ADAMs in Inflammatory Bowel Disease

    • Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko
    Pages 235-254

  12. Chemokines and Matrix Metalloproteinases in Colorectal Cancer

    • Gayle G. Vaday, Stanley Zucker
    Pages 255-300

  13. Angiotensin-Converting Enzyme (ACE) in Gut Inflammation

    • Fernando Magro
    Pages 301-314

  14. Intestinal Apical Protein Transport in Health and Disease

    • Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona et al.
    Pages 315-338

  15. Back Matter

    Pages 339-343
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Keywords

About this book

This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.

Editors and Affiliations

  • Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel

  • University of Leeds, United Kingdom

    Nigel M. Hooper

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