Aging at the Molecular Level

1. Front Matter

   Pages i-x

   PDF

2. Free Radical Production and Antioxidant Defense: A Primer

   • Nicolle Sitte, Thomas von Zglinicki

   Pages 1-10

3. Oxidative DNA Damage and Repair — Implications for Aging

   • Erling Seeberg

   Pages 11-25

4. Oxidative Damage to Proteins

   • Nicolle Sitte

   Pages 27-45

5. Aging Rate, Mitochondrial Free Radical Production, and Constitutive Sensitivity to Lipid Peroxidation: Insights From Comparative Studies

   • Reinald Pamplona, Gustavo Barja

   Pages 47-64

6. Genomic Instability in Human Premature Aging

   • Vilhelm A. Bohr, Patricia L. Opresko

   Pages 65-77

7. Oxidative Damage, Somatic Mutations and Cellular Aging

   • Rita A. Busuttil, Miguel Rubio, Martijn E. T. Dollé, Judith Campisi, Jan Vijg

   Pages 79-90

8. Mitochondria and Aging

   • Martin Barron, Doug Turnbull

   Pages 91-106

9. Biological Clocks in the Aging Cell

   • Petra Boukamp

   Pages 107-119

10. Telomeric Damage in Aging

    • Thomas von Zglinicki

    Pages 121-129

11. Probing the in Vivo Relevance of Oxidative Stress in Aging Using Knockout and Transgenic Mice

    • Florian L. Muller, James Mele, Holly Van Remmen, Arlan Richardson

    Pages 131-144

12. Non-oxidative Modification of DNA and Proteins

    • Alan R. Hipkiss

    Pages 145-177

13. Transcriptional and Translational Dysregulation During Aging

    • Suresh I. S. Rattan

    Pages 179-191

14. Metabolic Regulation of Gene Silencing and Life Span

    • Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair

    Pages 193-211

15. The Proteasome in Aging

    • Géraldine Carrard, Bertrand Friguet

    Pages 213-231

16. Aging and Lysosomal Degradation of Cellular Constituents

    • Alexei Terman, Ulf T. Brunk

    Pages 233-242

17. Back Matter

    Pages 243-248

    PDF

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation.
Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

• DNA
• Lipid
• Oxidation
• proteins
• regulation
• transcription
• translation

From the reviews:

"This volume is the first in a series of five in which the biology of ageing will be explored. … Altogether, this is a fairly comprehensive coverage of the current themes at the molecular level, with the further areas to be explored being well highlighted. The chapters are well-referenced and this timely text will be especially useful to those workers entering the field." (P.B.Gahan, Cell Biochemistry & Function, Vol. 23 (5), 2005)

• Henry Wellcome Laboratory for Biogerontology, Newcastle General Hospital, University of Newcastle, Newcastle upon Tyne, UK

  Thomas Zglinicki

Policies and ethics