Overview
- The application of modern quantitative MR techniques is changing dramatically our understanding of how MS causes irreversible disability
- These techniques evidence that MS is not only a white matter disease and that neurodegeneration is an important aspect of it
Part of the book series: Topics in Neuroscience (TOPNEURO)
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Table of contents (17 chapters)
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Background
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MRI Techniques to Assess Neurodegeneration
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Evaluation of MRI Outcomes
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Lessons from Other Neurodegenerative Diseases
Keywords
About this book
In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.
Reviews
From the reviews:
"This book is to ‘provide a complete and up-to-date overview of the technical, methodological, and clinical issues related to the application of MR imaging in MS trials of neurodegeneration.’ … the strength of this compact book would be its value as a compilation of material that is not so much novel as it is difficult to find in a single volume. … It will provide a convenient reference resource for MS investigators interested in the current status of neurodegeneration imaging studies in MS … ." (American Journal of Neuroradiology, Vol. 29, October, 2008)
Editors and Affiliations
About the editors
Dr. Massimo Filippi was born in 1961, took his Graduation in Medicine in 1986 and his Post-Degree Graduation in Neurology in 1990. His research activity has always been focussed on the use of MR-based technology to improve our understanding of how neurological diseases determine progressive accumulation of irreversible physical disability and cognitive impairment.
Dr. Filippi is member of various Scientific Societies and, in some of them, he covered or is covering institutional roles. He is also member of the Editorial Boards of many international scientific journals and acts as a reviewer on a regular basis for several others. He is author or co-author of more than 450 scientific papers published on peer-reviewed journals.
Dr. Filippi is currently Dierctor of the Neuroimaging Research Unit (NRU), Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, where he is also Non-Tenured Professor of Clinical Neurology. From 2005 he is also Director of the NMR Unit, Centro "S. Maria Nascente" IRCCS Fondazione Don Gnocchi, Milan.
Bibliographic Information
Book Title: Neurodegeneration in Multiple Sclerosis
Editors: Massimo Filippi, Marco Rovaris, Giancarlo Comi
Series Title: Topics in Neuroscience
DOI: https://doi.org/10.1007/978-88-470-0391-0
Publisher: Springer Milano
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer-Verlag Milan 2007
Hardcover ISBN: 978-88-470-0390-3Published: 06 August 2007
Softcover ISBN: 978-88-470-5583-4Published: 16 November 2014
eBook ISBN: 978-88-470-0391-0Published: 01 February 2008
Edition Number: 1
Number of Pages: XI, 236
Topics: Neurology, Neurosciences, Imaging / Radiology, Neuroradiology, Nuclear Medicine