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Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

  • Book
  • © 2004

Overview

Editors:
  1. Giancarlo Comi

    1. Department of Neurology Scientific Institute, University Ospedale San Raffaele, Milan, Italy

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  2. Massimo Filippi

    1. Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

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  3. Marco Rovaris

    1. Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

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Part of the book series: Topics in Neuroscience (TOPNEURO)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Normal-Appearing White Matter

    1. Front Matter

      Pages 1-1
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    2. Pathology of the Normal-Appearing White Matter in Multiple Sclerosis

      • W. Brück, C. Stadelmann
      Pages 3-8

    3. Measurement of Blood-Brain Barrier Permeability in Multiple Sclerosis

      • D. Soon, D. Miller
      Pages 9-22

    4. Measuring and Interpreting White Matter Volume Changes in Multiple Sclerosis

      • C. Wegner, S. Smith, P. M. Matthews
      Pages 23-35

    5. Normal-Appearing White Matter Changes in Multiple Sclerosis: Magnetization Transfer

      • F. Fazekas, C. Enzinger, S. Ropele
      Pages 37-45

    6. The Short T2 Component in Normal-Appearing White Matter in Multiple Sclerosis

      • A. MacKay, C. Laule, I. Vavasour, B. Mädler, A. Traboulsee, D. Paty et al.
      Pages 47-61

    7. Rapid, Whole-Brain T1 Relaxation Time Measurements for the Quantitative Definition of Pathological Changes in Multiple Sclerosis

      • A. M. Parry, S. Clare, P. M. Matthews
      Pages 63-77

    8. Diffusion-Weighted Imaging of the Normal-Appearing White Matter in Multiple Sclerosis

      • M. Rovaris, M. Filippi
      Pages 79-89

    9. The Relevance of Normal-Appearing White Matter Pathology in Multiple Sclerosis

      • M. MacInnes, D. L. Arnold
      Pages 91-97

  3. Normal-Appearing Grey Matter

    1. Front Matter

      Pages 99-99
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    2. Grey Matter Pathology in Multiple Sclerosis

      • B. P. Brink, S. J. Mork, P. Van Der Valk, L. Bo
      Pages 101-109

    3. Imaging Cerebral Grey Matter Volume in Multiple Sclerosis

      • N. De Stefano
      Pages 111-120

    4. The Grey Matter Component of MS Pathology: Magnetization Transfer and Diffusion-Weighted Imaging

      • M. A. Rocca, M. Filippi
      Pages 121-127

    5. MR Spectroscopy of the Normal-Appearing Grey Matter

      • O. Gonen, M. Inglese, R. I. Grossman
      Pages 129-143

    6. Functional MRI in Multiple Sclerosis

      • M. Filippi, M. A. Rocca
      Pages 145-155

  4. Back Matter

    Pages 157-159
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Keywords

About this book

In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.

Reviews

From the reviews:

"A large part of the text concerns the various magnetic resonance (MR) techniques which have been investigated for use as tools for quantification of the heterogeneous pathological change in multiple sclerosis (MS). The editors have brought together authors from the discipline of neuropathology, neurology and MRI to summarize their work. … A great deal of information is clearly and accurately presented. … This book is aimed at neuroscientists … . It may also be of interest to those treating patients with MS." (A. Campi, Neuroradiology, Vol. 48 (2), 2006)

Editors and Affiliations

  • Department of Neurology Scientific Institute, University Ospedale San Raffaele, Milan, Italy

    Giancarlo Comi

  • Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Massimo Filippi, Marco Rovaris

Bibliographic Information

  • Book Title: Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

  • Editors: Giancarlo Comi, Massimo Filippi, Marco Rovaris

  • Series Title: Topics in Neuroscience

  • DOI: https://doi.org/10.1007/978-88-470-2127-3

  • Publisher: Springer Milano

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Italia, Milano 2004

  • Hardcover ISBN: 978-88-470-0243-2Published: 09 August 2004

  • Softcover ISBN: 978-88-470-2175-4Published: 02 November 2012

  • eBook ISBN: 978-88-470-2127-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 159

  • Topics: Neurology, Imaging / Radiology, Neuroradiology

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