Engineered Cell Manipulation for Biomedical Application

1. Front Matter

   Pages i-viii

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2. Cell Manipulation for Control of Cell Function and Assembly for Tissue Engineering

   1. Front Matter

      Pages 1-1

      PDF

   2. Recent Advances in 3D Tissue Models

      • A. Kivelio, M. Ehrbar

      Pages 3-41

   3. Rapid Assembly of Cellular Aggregation Using Micro-Nano Technologies

      • Taisuke Masuda, Fumihito Arai

      Pages 43-55

   4. Rapid Single Cell Printing by Piezoelectric Inkjet Printer

      • Ryanto The, Shuichi Yamaguchi, Akira Ueno, Yoshitake Akiyama, Keisuke Morishima

      Pages 57-74

   5. Engineering Electrospun Scaffolds to Encourage Cell Infiltration

      • H. Sakaguchi, N. J. Amoroso, W. R. Wagner

      Pages 75-94

   6. The Potential Use of Three-Dimensional Cellular Multilayers as a Blood Vessel Model

      • Akihiro Nishiguchi, Michiya Matsusaki, Misturu Akashi

      Pages 95-129

   7. Engineering Cellular Assembly for Applications in Regenerative Medicine

      • Christopher Millan, Marcy Zenobi-Wong

      Pages 131-145

   8. Hepatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by Two- and Three-Dimensional Culture Systems In Vitro

      • Maiko Higuchi, Hiroyuki Mizuguchi

      Pages 147-157

   9. Reconstruction of Elastic Fibers in Three-Dimensional Smooth Muscle Cells

      • Utako Yokoyama, Yoshihiro Ishikawa

      Pages 159-174

   10. Building Experimental System Modeling Fibrotic Tissue in Human Pancreatic Cancer by Three-Dimensional Layer-by-Layer Culture

       • Mitsunobu R. Kano

       Pages 175-181

   11. Human Living Skin Equivalents as a Promising Model for Skin Grafts

       • Satoshi Hirakawa, Yuji Shirakata, Koji Hashimoto

       Pages 183-190

3. Cell Manipulation for Control of Cell Function for Drug Delivery System

   1. Front Matter

      Pages 191-191

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   2. Particulate and Immunity

      • Etsushi Kuroda, Cevayir Coban, Ken J. Ishii

      Pages 193-204

   3. Functional Nanoparticles for Vaccine Delivery Systems

      • Takami Akagi, Misturu Akashi

      Pages 205-228

   4. Nanoparticle-Based Specific Targeting of Antigen-Presenting Cells for Immunotherapy

      • Malin Lindstedt, Sissela Broos

      Pages 229-243

   5. Barrier Signalling

      • Saif Salih, Charles Patrick Case

      Pages 245-258

   6. The Absorption, Distribution, Metabolism, and Excretion Profile of Nanoparticles

      • Yasuo Yoshioka, Kazuma Higashisaka, Shin-ichi Tsunoda, Yasuo Tsutsumi

      Pages 259-271

4. Erratum: Chapter 11 Particulate and Immunity

   • Etsushi Kuroda, Cevayir Coban, Ken J. Ishii

   Pages E1-E1

This book is the first to summarize new technologies for engineered cell manipulation. The contents focus on control of cellular functions by nanomaterials and control of three-dimensional cell–cell interactions. Control of cellular functions is important for cell differentiation, maturation, and activation, which generally are controlled by the addition of soluble cytokines or growth factors into cell culture dishes. Target antigen molecules can be efficiently delivered to the cytosol of the dendritic cells using the nanoparticle technique described here, and cellular functions such as dendritic cell maturation can be controlled easily and with precision. This book describes basic preparation of the nanoparticles, activation control of dendritic cells, immune function control, and in vivo application for various vaccination systems. The second type of control,that of cell–cell interaction, is important for tissue engineering in order to develop three-dimensional cellular constructs. To achieve in vitro engineering of three-dimensional human tissue constructs, cell–cell interaction must be controlled in three dimensions, but typical biological cell manipulation technique cannot accomplish this task. An engineered cell manipulation technique is necessary. In this book the authors describe the fabrication of nanofilms onto cell surfaces, development of three-dimensional cellular multilayers, and various applications of the cellular multilayers as three-dimensional human models. This important work will be highly informative for researchers and students in the fields of materials science, polymer science, biomaterials, medicinal science, nanotechnology, biotechnology, and biology.

• Biodegradable Nanoparticles
• Hierarchical Cell Manipulation
• Layer-by-layer Nanofilms
• Layered Tissue Models
• Nanoparticle Vaccine

• Osaka University, Osaka, Japan

  Misturu Akashi, Takami Akagi, Michiya Matsusaki

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