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Organellar Proton-ATPases

  • Book
  • © 1995

Overview

Authors:
  1. Nathan Nelson

    1. Roche Institute of Molecular Biology, Roche Research Center, Nutley, USA

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Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Molecular and Cellular Biology of F- and V-ATPases

    • Nathan Nelson
    Pages 1-27

  3. An Overview of Intracellular pH Regulation: Role of Vacuolar H+-ATPases

    • Gergely Lukacs, Ori D. Rotstein, Sergio Grinstein
    Pages 29-47

  4. Acidification and Bone Resorption: The Role and Characteristics of V-ATPases in the Osteoclast

    • Roland Baron, Marcjanna Bartkiewicz, Pe’er David, Natividad Hernando-Sobrino
    Pages 49-73

  5. V-ATPases in Insects

    • Julian A. T. Dow
    Pages 75-102

  6. Mitochondrial ATP Synthase: Structure, Biogenesis and Pathology

    • Howard T. Jacobs
    Pages 103-161

  7. Properties of Kidney Plasma Membrane Vacuolar H+-ATPases: Proton Pumps Responsible for Bicarbonate Transport, Urinary Acidification, and Acid-Base Homeostasis

    • Stephen L. Gluck, Raoul D. Nelson, Beth S. M. Lee, L. Shannon Holliday, Masahiro Iyori
    Pages 163-221

  8. Back Matter

    Pages 223-228
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Keywords

About this book

THE WORLD OF PROTON PUMPS Nathan Nelson uite frequently an observer looks at a life phenomenon and asks ~himself why nature took this route out of several other available mec anisms. In order to understand this challenge he may first try to reconstruct the evolution of the process taking into account the main driving forces that were assumed to exist during the last 3. 5 billion years on earth. Now we know that the electrochemical gradient of protons is the universal high-energy intermediate produced and uti­ lized by every living cell in nature. This high energy intermediate is an expression of different concentrations of active protons in the two faces of biological membranes. Why then did nature elect to utilize a pre­ dominantly electrochemical gradient of protons and no other ion? The answer to this question may lie in the environment in which the first living creatures evolved. Some of them may have been challenged by an acidic environment that lowered their internal pH (by a proton leak through their membranes) to lethal levels. To counteract these inci­ dents proton pumps evolved. Two independent systems were devel­ oped. One was a proton pump coupled to energetically downhill vectorial electron transport across membranes and the second was an ATP-dependent proton pump. Both of them pump protons outward from the cells generating an electrochemical gradient of protons.

Authors and Affiliations

  • Roche Institute of Molecular Biology, Roche Research Center, Nutley, USA

    Nathan Nelson

Bibliographic Information

  • Book Title: Organellar Proton-ATPases

  • Authors: Nathan Nelson

  • Series Title: Molecular Biology Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22265-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-662-22267-6Published: 23 August 2014

  • eBook ISBN: 978-3-662-22265-2Published: 29 June 2013

  • Series ISSN: 1431-0414

  • Edition Number: 1

  • Number of Pages: XIV, 228

  • Number of Illustrations: 28 b/w illustrations

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Austin, USA

  • Topics: Cell Biology

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