Testicular Tangrams

1. Front Matter

   Pages I-XIII

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2. Multiple Guardians of the Epithelial Stage IV Meiotic Checkpoint

   • T. Ashley

   Pages 1-18

3. Role of Sertoli Cells in Hypospermatogenesis Induced by Antiandrogens

   • M. Benahmed, F. Chuzel, R. Bars, A. Omezzine, C. Mauduit, L. Benbrahim-Tallaa et al.

   Pages 19-28

4. Understanding the Mutation-Induced Activation of the Lutropin Receptor from Computer Simulation

   • F. Fanelli

   Pages 29-38

5. Sex-Specific Differences in the Control of Mammalian Gametogenesis: Vive la Difference!

   • D. J. Wolgemuth

   Pages 39-53

6. Cloning and Characterization of Male Germ-Cell-Specific Genes

   • H. Tanaka, M. Nozaki, K. Yomogida, Y. Nishimune

   Pages 55-73

7. Control of Spermatogenesis via Sertoli Cells

   • M. D. Griswold, D. McLean

   Pages 75-84

8. Gene-Modified Animal Models for the Study of Luteinizing Hormone and Luteinizing Hormone Receptor Function

   • F.-P. Zhang, M. Poutanen, I. Huhtaniemi

   Pages 85-97

9. Analysing Differential Gene Expression in the Testis

   • R. Ivell, A.-N. Spiess

   Pages 99-120

10. Spermatogonial Stem Cell Development

    • D. G. de Rooij, L. B. Creemers, K. den Ouden, F. Izadyar

    Pages 121-138

11. Multimeric Coactivator Complexes for Steroid/Nuclear Receptors

    • L. P. Freedman

    Pages 139-149

12. DAX1 and SF1 Mutations Provide Insight into Sexual Differentiation

    • G. Ozisik, J. C. Achermann, J. J. Meeks, J. L. Jameson

    Pages 151-171

13. Back Matter

    Pages 173-176

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During the past two decades research on the testis has created a vast number of publications. New techniques, such as cell and gene clon­ ing, germ cell manipulation and transplantation, as well as gene ex­ pression, have surpassed the classical approaches that involved studies on receptor activation and endocrine, paracrine and autocrine regula­ tory mechanisms. Due to the expansion of this field of research it has become increasingly difficult to integrate the large number of observa­ tions and relate them to the physiology and pathophysiology of the tes­ tis. More emphasis must, therefore, be put on the integration of isolated findings and the construction of the total picture. In order to stimulate this specific mental activity we have named this book Testicular Tan­ gram. We hope that the chapters in this book will be used as pieces of the testicular puzzle and that the reader enjoys composing new shapes. The chapters of this book are representative of the plenary lectures presented at the I ih European Workshop on Molecular and Cellular Endocrinology of the Testis held in Doorwerth The Netherlands, from April 6 - I 0, 2002. Publication of this book has been made possible by the generous support of the Ernst Schering Research Foundation. We would also like to thank the distinguished scientists, who have pro­ vided us with their excellent manuscripts well before the start of the Workshop. We acknowledge the help of Dr. U. -F. Habenicht, Dr. M.

• Leydig Cells
• Meiosis
• Sertoli Cells
• Spermatids
• Spermatogonial Stem Cells
• cloning
• endocrinology
• gene expression
• hormone
• nuclear receptors
• reproduction
• spermatogenesis
• stem cells
• steroid
• testis

• Department of Internal Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands

  F. F. G. Rommerts

• Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  K. J. Teerds

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