Biological Modulation of Solid Tumours by Interferons

1. Front Matter

   Pages i-vii

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2. Introduction

   • K. Pummer

   Pages 1-2

3. The Interferons: Basic Concepts Concerning their Modulatory Effects on the Immunological System

   • M. Alvarez-Mon, J. Keller, L. Molto, L. Manzano, E. Reyes, M. Rodriguez-Zapata et al.

   Pages 3-12

4. Biomodulation of 5-Fluorouracil by Interferon-Alpha

   • H. Stöger, H. Samonigg

   Pages 13-25

5. Malignant Melanoma

   • G. Parmiani, A. Mazzocchi

   Pages 27-35

6. Head and Neck Cancer

   • H. Bier, W. Bergler

   Pages 37-44

7. Breast Cancer

   • J. M. Ferrero, M. Namer

   Pages 45-51

8. Renal Cell Carcinoma

   • P. A. Ruffini, C. Gambacorti-Passerini

   Pages 53-60

9. Prostate Cancer

   • K. Pummer, P. Pürstner, G. Lanzer, U. Pätzold, H. L. Auner

   Pages 61-75

In the 1960s, it was reported that interferons have antitumour activity in different experimental models. Since that time, numerous studies have been performed to elucidate the various mechanisms of action that have been proposed. However, there is much controversy in the literature and promising preclinical findings failed to translate into substantial clinical progress. The present book gives a critical overview of current knowledge of how interferons act in solid tumours. For this purpose, after two chapters of general aspects of interferon action and interaction, selected solid tumours which are commonly considered difficult to treat in advanced stages are discussed with respect to both preclinical data and clinical experience.

• Biological therapy
• Solid Tumour
• breast cancer
• cancer
• carcinoma
• cell
• head and neck cancer
• interferon
• malignant melanoma
• melanoma
• prostate cancer
• renal cell carcinoma
• tumor

• Universitätsklinik für Urologie, Graz, Austria

  Karl Pummer

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