Clinical Pharmacology in Psychiatry

1. Front Matter

   Pages I-XIV

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2. Strategies in Psychotropic Drug Innovation

   1. Front Matter

      Pages 1-1

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   2. Receptor Subtypes and Endogenous Ligands: Rational Tools in the Search for Psychotropic Drugs

      • C. Braestrup, P. H. Andersen

      Pages 3-9

   3. Histamine H3 Receptors in the Brain: Potent and Selective Ligands

      • J. C. Schwartz, J. M. Arrang, M. Garbarg, H. Pollard

      Pages 10-19

   4. Targets for Neurotransmitter Receptor Research Using PET Scan: The Neuroleptic Binding Site

      • J. C. Baron, J. L. Martinot, H. Cambon, J. P. Boulenger, M. F. Poirier, V. Caillard et al.

      Pages 20-31

   5. The Potential of Positron-Emission Tomography for Pharmacokinetic and Pharmacodynamic Studies of Neuroleptics

      • L. Farde, F.-A. Wiesel, L. Nilsson, G. Sedvall

      Pages 32-39

   6. Neurotransmitter Interactions as a Target of Drug Action

      • W. Z. Potter, J. K. Hsiao, H. Ågren

      Pages 40-51

   7. E-10-Hydroxynortriptyline: Effects and Disposition of a Potential Novel Antidepressant

      • L. Bertilsson, M.-L. Dahl-Puustinen, C. Nordin

      Pages 52-59

   8. Molecular Graphics of Antidepressant Drugs and Metabolites

      • S. G. Dahl, Ø. Edvardsen, E. Heimstad

      Pages 60-67

   9. Negative Symptoms in Schizophrenia: A Target for New Drug Development

      • H. Y. Meltzer, J. Zureick

      Pages 68-77

3. Clinical Significance of Receptor-Selective Drugs

   1. Front Matter

      Pages 79-79

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   2. Clinical Effects of Selective Serotonin Reuptake Inhibitors

      • P. Bech

      Pages 81-93

   3. Effects of Serotonergic Agonists on Neuroendocrine Responses of Rhesus Monkeys and Patients with Depression and Anxiety Disorders

      • G. R. Heninger, D. S. Charney, L. H. Price, P. Delgado, S. Woods, W. Goodman

      Pages 94-104

   4. Theoretical and Practical Implications of a Controlled Trial of an α2-Adrenoceptor Antagonist in the Treatment of Depression

      • S. A. Montgomery

      Pages 105-108

   5. Selective Dopamine D1 and D2 Receptor Antagonists

      • J. Hyttel, J. Arnt, M. van den Berghe

      Pages 109-122

   6. Animal Pharmacology of Raclopride, a Selective Dopamine D2 Antagonist

      • H. Hall, S. O. Ögren, C. Köhler, O. Magnusson

      Pages 123-130

   7. Benzodiazepine Receptor Subtypes and Their Possible Clinical Significance

      • W. Sieghart

      Pages 131-137

4. Pharmacogenetics in Psychopharmacology

   1. Front Matter

      Pages 139-139

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   2. Genetic Polymorphisms of Drug-Metabolizing Enzymes: Molecular Mechanisms

      • U. A. Meyer, U. Zanger, R. Skoda, D. M. Grant

      Pages 141-147

   3. Genetic Polymorphism in Drug Oxidation

      • W. Kalow

      Pages 148-162

This volume collects the invited lectures and some selected contributions presented at the 5th International Meeting on Clinical Pharmacology in Psychiatry, which was held 26-30 June 1988 at the University of Troms0, Norway. The 24 h of daylight at the northernmost university in the world al­ lowed for long, pleasant and productive sessions. The title of the conference as well as a number of the topics covered represent a continuation of four previous conferences, the first held in Chicago in 1979 and organized by the late Earl U sdin and colleagues. The earlier conferences have been documented in Clinical Pharmacology in Psychiatry, edited by E. Usdin (Elsevier, New York, 1981), Clinical Pharmacology in Psychiatry. Neuroleptic and Antidepressant Research, edited by E. Usdin, S. G. Dahl, L. F. Gram and o. Lingjrerde (Macmillan Publishers Ltd., London, 1981), Clinical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic Gap, edited by LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P. L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London, 1983), and Clinical Pharmacology in Psychiatry. Selectivity in Psychotropic Drug Action - Promises or Problems? edited by S. G. Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology Series 3, Springer, Heidelberg, 1987).

• Psychogenetik
• Psychokinetik
• Psychotropic drugs
• Psychotropische Substanzen
• clinical research
• drug
• kinetics
• metabolism
• pharmacokinetics
• pharmacology
• psychiatric disorder
• psychiatry
• psychopharmacology
• receptor selectivity
• research

• Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, Tromsø, Norway

  Svein G. Dahl

• Department of Clinical Pharmacology, School of Medicine, Odense University, Odense C, Denmark

  Lars F. Gram

Policies and ethics