Mechanisms and Models in Toxicology

1. Front Matter

   Pages I-VIII

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2. Mechanisms of Cell Injury

   1. Front Matter

      Pages 1-1

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   2. Apoptosis: Cell Death Under Homeostatic Control

      • A. H. Wyllie

      Pages 3-10

   3. On The Role of Calcium in Chemical Toxicity

      • S. Orrenius, P. Nicotera

      Pages 11-19

   4. A Dynamic Liver Culture System: A Tool for Studying Chemical Biotransformation and Toxicity

      • I. G. Sipes, R. L. Fisher, P. F. Smith, E. R. Stine, A. J. Gandolfi, K. Brendel

      Pages 20-33

   5. Some Aspects of Cell Defense Mechanisms of Glutathione and Vitamin E During Cell Injury

      • D. J. Reed, G. A. Pascoe, K. Olafsdottir

      Pages 34-38

   6. Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures

      • D. F. V. Lewis, B. G. Lake, T. J. B. Gray, S. D. Gangolli

      Pages 39-41

   7. Oxidative and Reductive Biotransformation of Chloroform in Mouse Liver Microsomes

      • E. Testai, F. Gramenzi, S. Di Marzio, L. Vittozzi

      Pages 42-44

   8. Effects of Subchronic Low-Protein Diet on Some Tissue Glutathione - Related Enzyme Activities in the Rat

      • J.-M. Warnet, I. Bakar-Wesseling, M. Thevenin, J. J. Serrano, A. Jacqueson, M. Boucard et al.

      Pages 45-49

3. Mechanisms in Cancer Risk Assesment

   1. Front Matter

      Pages 51-51

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   2. Interorgan Shift of Nitrosamine Metabolism by Dietary Ethanol

      • O. D. Wiestler, A. von Deimling, E. von Hofe, I. Schmerold, E. Wiestler, P. Kleihues

      Pages 53-65

   3. Quantitative Evaluation of DNA-Binding Data In Vivo for Low-Dose Extrapolations

      • W. K. Lutz

      Pages 66-74

   4. Persistent Organ Damage and Cancer Production in Rats and Mice

      • P. Grasso

      Pages 75-83

   5. Sensitivity of DNA and Nucleotides to Oxidation by Permanganate and Hydrogen Peroxide

      • P. Sagelsdorff, W. K. Lutz

      Pages 84-88

   6. A Postlabelling Assay for N7-(2-Oxoethyl)Guanine, the Principal Vinyl Chloride-DNA Adduct

      • W. P. Watson, A. E. Crane, R. Davis, R. J. Smith, A. S. Wright

      Pages 89-92

   7. Comparison of Hydrocarbon – DNA Adducts Formed in Mouse and Human Skin Following Treatment with Benzo [A] Pyrene

      • W. P. Watson, R. J. Smith, K. R. Huckle, A. S. Wright

      Pages 93-98

   8. Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB)

      • R. H. Dashwood, R. D. Combes, J. Ashby

      Pages 99-101

4. Mechanisms and Models of Teratogenesis

   1. Front Matter

      Pages 103-103

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   2. Teratogenicity Testing in Vitro: Status of Validation Studies

      • N. A. Brown

      Pages 105-114

   3. The Primate as a Model for Hazard Assessment of Teratogens in Humans

      • R. Korte, F. Vogel, I. Osterburg

      Pages 115-121

This supplement presents the papers submitted at the 27th meeting of the European Society of Toxicology, which was organised by the British Toxicology Society and held in Harrogate, England. As evident from the title of this book, the overall theme of the meeting was an exploration of some of the mechanisms of toxicity, as well as some models used in the investigation of toxic action. The topics dealt with can be grouped under four headings. The first of these, on the mechanisms involved in cell injury, was a joint symposium of the European Society of Toxicology and the Society of Toxicology of the United States of America. In the second group, mechanisms in carcinogen risk assessment were discussed. Mechanisms and models of teratogenesis was the subject of the third group of invited papers. Finally, a workshop on safety evaluation of biotechnological products dealt with present and future problems which this new area of technology poses for toxicologists. Short communications on recent studies and developments in toxicological techniques which were presented at the meeting are also included in this volume.

• biotechnology
• cancer
• cancer risk
• toxicity
• toxicology

• Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

  Claire M. Chambers, Philip L. Chambers

• Royal Postgraduate Medical School, London, UK

  Donald S. Davies

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