Lesion-Induced Neuronal Plasticity in Sensorimotor Systems

1. Front Matter

   Pages I-XII

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2. General Aspects of Lesion-Induced Neuronal Plasticity

   1. Front Matter

      Pages 1-1

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   2. The Significance of Neuronal Cell Death During the Development of the Nervous System

      • G. Rager

      Pages 3-12

   3. The Critical Afferent Theory: A Mechanism to Account for Septohippocampal Development and Plasticity

      • C. W. Cotman, E. R. Lewis, D. Hand

      Pages 13-26

   4. The Regulation of Sprouting in the Adult Hippocampus: Some Insights from Developmental Studies

      • C. Gall, G. Lynch

      Pages 27-37

   5. Formation and Regression of Synaptic Contacts in the Adult Muscle

      • A. Wernig, A. P. Anzil, A. Bieser

      Pages 38-50

   6. Morphological and Physiological Effects of Axotomy on Cat Abducens Motoneurons

      • R. Baker, J. Delgado-Garcia, R. McCrea

      Pages 51-63

   7. Neuronal Plasticity in the Newborn and Adult Feline Red Nucleus

      • N. Tsukahara, Y. Fujito

      Pages 64-74

   8. Neurochemistry of Synaptic Renewal

      • J. J. Bernstein, D. Ganchrow, M. R. Wells

      Pages 75-86

   9. Changes in Neurotransmitter Synthesizing Enzymes During Regenerative, Compensatory, and Collateral Sprouting of Central Catecholamine Neurons in Adult and Developing Rats

      • D. J. Reis, R. A. Ross, L. Iacovitti, G. Gilad, T. H. Joh

      Pages 87-102

   10. Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function

       • D. S. Forman, I. G. McQuarrie, B. Grafstein, D. L. Edwards

       Pages 103-113

3. Sensorimotor Subsystems: Experimental Models and Techniques

   1. Front Matter

      Pages 115-115

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   2. Primary Afferent Synaptic Modulation as a Mechanism of Behavioral Compensation Following Spinal Cord Lesion in the Frog

      • A. R. Blight, W. Precht

      Pages 117-129

   3. The Role Sprouting Might Play During the Recovery of Motor Function

      • M. E. Goldberger

      Pages 130-140

   4. Functional Synaptic Changes Caudal to Spinal Cord Transection

      • L. M. Mendell, S. G. Nelson, T. C. Cope, T. C. Cope

      Pages 141-150

4. Recovery from Vestibular Lesions

   1. Front Matter

      Pages 151-151

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   2. Concepts of Vestibular Compensation

      • H. Flohr, H. Bienhold, W. Abeln, I. Macskovics

      Pages 153-172

   3. An Ontogenetic Approach to Vestibular Compensation Mechanisms

      • E. Horn

      Pages 173-183

   4. Functional Restitution of Static and Dynamic Reflexes in the Frog After Hemilabyrinthectomy

      • N. Dieringer, W. Precht

      Pages 184-196

   5. Aspects of Vestibular Compensation in Guinea Pigs

      • K.-P. Schaefer, D. L. Meyer

      Pages 197-207

Sensorimotor systems are not rigidly wired predetermined networks but rather highly plastic structures that learn and modify their entire performance in response to changes in external or internal conditions. Lesions or distortions of the system's input, which initially cause a functional disorganization, induce an active reorganization which often leads to a recovery of function. Examples of lesion-induced neural plasticity have been known for some hundred years; however, an awareness of their value as research tools is relatively new. This current interest is a consequence of rapid­ ly changing ideas concerning the nature of CNS organization. Out of these, concepts are emerging which describe neural nets as modifiable, highly dynamic, self-organizing structures. This trend is clearly reflected in this volume, which contains the proceedings of a symposium held in Bremen in July 1980 as a satellite meeting of the XXVIIIth International Congress of Physiological Sciences. The first part of this conference was devoted to some gen­ eral aspects of plasticity, discussing the current theories of functional recovery as well as morphological, neurochemical, physiological, molecular, and ontogenetic aspects. The second part dealt with lesion­ induced plasticity in specific sensorimotor systems of the spinal cord, brain stem, and cerebral cortex.

• Nervenregeneration
• Nervenverletzung
• Plasticity
• Sensumotorische Störung
• cortex

• Universität Bremen, Bremen 33, Germany

  Hans Flohr

• Institut für Hirnforschung, Universität Zürich, Zürich, Switzerland

  Wolfgang Precht

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