With the aim of providing an international forum for the communication of both the basic and clinical aspects of molecular and cellular biology of cancer, a NATO ASl was held in Porto Carras, Halkidiki, Greece, September 1-12, 1995. The principles as well as recent developments in tumor biology were discussed in depth, with emphasis on the regulation of the cell cycle, differentiation, programmed cell death (apoptosis) and genetics of cancer. This book constitutes the proceedings of that meeting. Specifically, the following areas were addressed: (a) enzymes and proteins (cyclins) that control the cell cycle, as well as the role of m as gene in meiosis and transformation; (b) the structural basis for specificity in protein-tyrosine kinase reactions; (c) the differentiation of normal as well as neoplastic cells with respect to molecular mechanism(s) by which chemical agents or growth factors trigger maturation; (d) phenotypic and genetic aspects of apoptosis; (e) the role of growth factors, like IGF-l, FGF, TN, IL-6, etc. , in cell cycle regulation, apoptosis (cell death) and senescence; (f) molecular mechanisms of transcriptional activation of globin genes and stability of mRNAs related to growth proteins and iron metabolism; (g) the cellular and molecular biology of bone marrow hemopoiesis; and (h) neurotrophic factors and the generation of cellular diversity in the central nervous system. It was obvious from the studies presented that neoplastic cell growth, differentiation and apoptosis in many cell types are regulated at several levels.
Editors and Affiliations
Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Asterios S. Tsiftsoglou
Department of Pharmacology, Yale University School of Medicine, New Haven, USA
Alan C. Sartorelli
Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
David E. Housman
Department of Experimental Hematology, Christie Hospital, NHS Trust Paterson Institute for Cancer Research, Manchester, UK
T. Michael Dexter
Bibliographic Information
Book Title: Tumor Biology
Book Subtitle: Regulation of Cell Growth, Differentiation and Genetics in Cancer
Editors: Asterios S. Tsiftsoglou, Alan C. Sartorelli, David E. Housman, T. Michael Dexter
