Gene Vaccination: Theory and Practice

1. Front Matter

   Pages I-X

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2. Introduction: gene vaccination, current concepts and future directions

   • Eyal Raz

   Pages 1-7

3. Plasmid DNA vaccination: mechanism of antigen presentation

   • Maripat Corr, Helen Tighe

   Pages 9-15

4. The development of a multivalent DNA vaccine for malaria

   • Richard C. Hedstrom, Denise L. Doolan, Ruobing Wang, Malcolm J. Gardner, Anita Kumar, Martha Sedegah et al.

   Pages 17-29

5. Genetic adjuvants for DNA immunization

   • Robert B. Mendoza, Thomas J. Kipps

   Pages 31-38

6. Gene immunization for the induction of antigen-specific, non MHC-restricted responses

   • Delphine J. Lee, Dennis A. Carson, Maripat Corr

   Pages 39-49

7. DNA vaccines with rapid intracellular degradation are more effective for inducing CTL

   • Yunqi Wu, Thomas J. Kipps

   Pages 51-57

8. Genetic vaccination against tuberculosis

   • Douglas B. Lowrie, Celio L. Silva, Ricardo E. Tascon

   Pages 59-71

9. DNA gene vaccination for HIV

   • Jong J. Kim, David B. Weiner

   Pages 73-92

10. DNA-based immunization against hepatitis B virus

    • Heather L. Davis, Cynthia L. Brazolot Millan

    Pages 93-107

11. Gene vaccination for hepatitis C

    • Geneviève Inchauspé

    Pages 109-119

12. Gene immunization for allergic disorders

    • Mark Roman, Hans L. Spiegelberg, David Broide, Eyal Raze

    Pages 121-130

13. Immunization with DNA vaccines in early life: advantages and limitations as compared to conventional vaccines

    • Claire-Anne Siegrist, Paul-Henri Lambert

    Pages 131-141

14. DNA vaccination by somatic transgene immunization

    • Maurizio Zanetti, Sidong Xiong, Mara Gerloni

    Pages 143-156

15. DNA vaccines: safety and efficacy issues

    • Dennis M. Klinman, Mitsuhiro Takeno, Motohide Ichino, Mili Gu, Galina Yamshchikov, Gil Mor et al.

    Pages 157-168

16. Genetic vaccines — a revolution in vaccinology?

    • Z. Q. Xiang, S. Pasquini, Z. He, H. Deng, Y. Wang, M. A. Blaszczyk-Thurin et al.

    Pages 169-180

Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.

• Antigen
• DNA
• HIV
• genes
• genetic vaccination
• hepatitis
• immunization
• infectious disease
• malaria
• plasmid vaccination

• Department of Medicine, University of California, San Diego, La Jolla, USA

  Eyal Raz

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