Mechanism of Action

1. Front Matter

   Pages I-XII

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2. Penicillins and Cephalosporins

   • Edwin H. Flynn, Carl W. Godzeski

   Pages 1-19

3. Penicillins and Cephalosporins

   • Carl W. Godzeski, Edwin H. Flynn

   Pages 20-39

4. D-Cycloserine and O-Carbamyl-D-serine

   • Francis C. Neuhaus

   Pages 40-83

5. Ristocetin

   • D. C. Jordan

   Pages 84-89

6. Bacitracin

   • Eugene D. Weinberg

   Pages 90-101

7. Vancomycin

   • D. C. Jordan, P. E. Reynolds

   Pages 102-116

8. Pyocyanine

   • P. G. Caltrider

   Pages 117-121

9. Polyene Antibiotics

   • Stephen C. Kinsky

   Pages 122-141

10. Polymyxins and Circulin

    • Oldrich K. Sebek

    Pages 142-152

11. Albomycin

    • B. K. Bhuyan

    Pages 153-155

12. Sarkomycin

    • Shan-ching Sung

    Pages 156-165

13. Pluramycin

    • Nobuo Tanaka

    Pages 166-168

14. Edeine and Pactamycin

    • B. K. Bhuyan

    Pages 169-172

15. Phleomycin, Xanthomycin, Streptonigrin, Nogalamycin, and Aurantin

    • B. K. Bhuyan

    Pages 173-180

16. Griseofulvin

    • Floyd M. Huber

    Pages 181-189

17. Daunomycin and Related Antibiotics

    • A. Di Marco

    Pages 190-210

18. The Mitomycins and Porfiromycins

    • W. Szybalski, V. N. Iyer

    Pages 211-245

19. Chromomycin, Olivomycin and Mithramycin

    • G. F. Gause

    Pages 246-258

20. Puromycin

    • Daniel Nathans

    Pages 259-277

The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio­ graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for­ ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master. That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and bio­ synthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.

• Chloramphenicol
• Tetracycline
• antibiotics
• bacteria
• biology
• biosynthesis
• cell
• chemistry
• microbiology
• protein

• University of Illinois, Urbana, USA

  David Gottlieb, Paul D. Shaw

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