Overview
- The first book to investigate protein-nanoparticle interactions in detail
- Gives an overview on the applications and safety issues resulting involved
- Written by international experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Series in Biophysics (BIOPHYSICS, volume 15)
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Table of contents (4 chapters)
Keywords
About this book
In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing.
In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Authors and Affiliations
Bibliographic Information
Book Title: Protein-Nanoparticle Interactions
Book Subtitle: The Bio-Nano Interface
Authors: Masoud Rahman, Sophie Laurent, Nancy Tawil, L'Hocine Yahia, Morteza Mahmoudi
Series Title: Springer Series in Biophysics
DOI: https://doi.org/10.1007/978-3-642-37555-2
Publisher: Springer Berlin, Heidelberg
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2013
Hardcover ISBN: 978-3-642-37554-5Published: 04 July 2013
Softcover ISBN: 978-3-642-44068-7Published: 08 February 2015
eBook ISBN: 978-3-642-37555-2Published: 24 June 2013
Series ISSN: 0932-2353
Series E-ISSN: 1868-2561
Edition Number: 1
Number of Pages: X, 84
Number of Illustrations: 4 b/w illustrations, 20 illustrations in colour
Topics: Biochemistry, general, Protein-Ligand Interactions, Pharmacology/Toxicology, Biological and Medical Physics, Biophysics, Nanoscale Science and Technology, Nanotechnology