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Epigenetic Mechanisms in Cellular Reprogramming

  • Book
  • © 2015

Overview

Editors:
  1. Alexander Meissner

    1. Dpt. of Stem Cell and Regenerative Biol, Harvard University Broad Institute, Bauer Laboratory, Cambridge, USA

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  2. Jörn Walter

    1. Dpt. of Genetics & Epigenetics, Universität des Saarlandes FR 8.4 Biosciences, Saarbrücken, Germany

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  • Contains translational medicine aspects such as B cell programming and reprogramming in cancer
  • Includes extensive glossary
  • Understanding stem cell formation is key to develop novel drugs

Part of the book series: Epigenetics and Human Health (EHH)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xviii
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  2. The Oocyte Determinants of Early Reprogramming

    • Caroline Schwarzer, Michele Boiani
    Pages 1-29

  3. Stella and Zygotic Reprogramming

    • Toshinobu Nakamura, Toru Nakano
    Pages 31-42

  4. Histone Variants and Reprogramming in Early Development

    • Ana Bošković, Maria-Elena Torres-Padilla
    Pages 43-68

  5. DNA Methylation Reprogramming in Preimplantation Development

    • Konstantin Lepikhov, Julia Arand, Sarah Fuchs, Jie Lan, Mark Wossidlo, Jörn Walter
    Pages 69-99

  6. Establishing and Maintaining Pluripotency: An Epigenetic Perspective

    • Jing Liao, Alexander Meissner
    Pages 101-120

  7. Epigenetic Regulation of Pluripotency by Polycomb Group Proteins

    • Achim Breiling
    Pages 121-139

  8. PRC1-Mediated Gene Silencing in Pluripotent ES Cells: Function and Evolution

    • Matthias Becker, Nancy Mah, Daniela Zdzieblo, Xiaoli Li, Arvind Mer, Miguel A. Andrade-Navarro et al.
    Pages 141-166

  9. The Biology and Genomic Localization of Cytosine Modifications

    • Gordon R. McInroy, Neil M. Bell, Gabriella Ficz, Shankar Balasubramanian, Wolf Reik, Eun-Ang Raiber
    Pages 167-191

  10. Epigenetic Reprogramming in Cancer

    • Anders M. Lindroth, Yoon Jung Park, Christoph Plass
    Pages 193-223

  11. Back Matter

    Pages 225-230
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Keywords

About this book

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.

Editors and Affiliations

  • Dpt. of Stem Cell and Regenerative Biol, Harvard University Broad Institute, Bauer Laboratory, Cambridge, USA

    Alexander Meissner

  • Dpt. of Genetics & Epigenetics, Universität des Saarlandes FR 8.4 Biosciences, Saarbrücken, Germany

    Jörn Walter

Bibliographic Information

  • Book Title: Epigenetic Mechanisms in Cellular Reprogramming

  • Editors: Alexander Meissner, Jörn Walter

  • Series Title: Epigenetics and Human Health

  • DOI: https://doi.org/10.1007/978-3-642-31974-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-642-31973-0Published: 05 January 2015

  • Softcover ISBN: 978-3-662-51062-9Published: 24 September 2016

  • eBook ISBN: 978-3-642-31974-7Published: 11 December 2014

  • Series ISSN: 2191-2262

  • Series E-ISSN: 2191-2270

  • Edition Number: 1

  • Number of Pages: XVIII, 230

  • Number of Illustrations: 1 b/w illustrations, 19 illustrations in colour

  • Topics: Human Genetics, Cell Biology, Systems Biology, Nucleic Acid Chemistry

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