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Environmental Epigenomics in Health and Disease

Epigenetics and Disease Origins

  • Book
  • © 2013

Overview

Editors:
  1. Randy L Jirtle

    1. School of Medicine and Public Health, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, USA

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  2. Frederick L. Tyson

    1. National Institute of Environmental Hea, NIEHS, National Institutes of Health, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides evidence that environmental exposures during early development can alter the risk of developing medical conditions
  • Presents epigenetic processes that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females.
  • Summarizes the latest epigenetic advances in the understanding of cancer development and progression, with a special focus on DNA methylation alterations and their value in clinical oncology for cancer management
  • Includes supplementary material: sn.pub/extras

Part of the book series: Epigenetics and Human Health (EHH)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xv
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  2. Fetal Origins of Adult Disease Susceptibility

    1. Front Matter

      Pages 1-1
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    2. Epigenetics: How Genes and Environment Interact

      • Randy L. Jirtle
      Pages 3-30

    3. Developmental Epigenomics and Metabolic Disease

      • Peter D. Gluckman, Felicia M. Low, Mark A. Hanson
      Pages 31-50

    4. Sculpting Our Future: Environmental Nudging of the Imprintome

      • Susan K. Murphy, Cathrine Hoyo
      Pages 51-73

  3. Epigenetics and Environmental Exposures

    1. Front Matter

      Pages 75-75
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    2. Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures

      • Christopher Faulk, Dana C. Dolinoy
      Pages 77-97

    3. Epigenetic Effects of Ionizing Radiation

      • Olga Kovalchuk
      Pages 99-126

    4. The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury

      • Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya-Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos et al.
      Pages 127-160

  4. Epigenetics, Gene Regulation, and Stem Cells

    1. Front Matter

      Pages 161-161
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    2. Environmental Impact on Epigenetic Histone Language

      • John M. Denu
      Pages 163-187

    3. Chromatin Structure and Gene Expression: Function Follows Form

      • Aleksandra B. Adomas, Paul A. Wade
      Pages 189-205

    4. Epigenetics of Pluripotency

      • R. David Hawkins, Bing Ren
      Pages 207-223

  5. Epigenetic Transgenerational Inheritance

    1. Front Matter

      Pages 225-225
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    2. Transgenerational Epigenetic Inheritance in Drosophila

      • Luan Wang, Xiangyi Lu, Douglas M. Ruden
      Pages 227-244

    3. Environmental Epigenetics and Epigenetic Transgenerational Inheritance

      • Michael K. Skinner
      Pages 245-256

    4. The Nature of Human Transgenerational Responses

      • Marcus E. Pembrey, Lars O. Bygren, Jean Golding
      Pages 257-271

  6. Back Matter

    Pages 273-302
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Keywords

About this book

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Editors and Affiliations

  • School of Medicine and Public Health, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, USA

    Randy L Jirtle

  • National Institute of Environmental Hea, NIEHS, National Institutes of Health, Research Triangle Park, USA

    Frederick L. Tyson

Bibliographic Information

  • Book Title: Environmental Epigenomics in Health and Disease

  • Book Subtitle: Epigenetics and Disease Origins

  • Editors: Randy L Jirtle, Frederick L. Tyson

  • Series Title: Epigenetics and Human Health

  • DOI: https://doi.org/10.1007/978-3-642-23380-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-23379-1Published: 29 May 2013

  • Softcover ISBN: 978-3-642-42728-2Published: 15 June 2015

  • eBook ISBN: 978-3-642-23380-7Published: 16 May 2013

  • Series ISSN: 2191-2262

  • Series E-ISSN: 2191-2270

  • Edition Number: 1

  • Number of Pages: XV, 302

  • Topics: Human Genetics, Cancer Research, Gene Function

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