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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 199)
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Table of contents (6 chapters)
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Front Matter
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Back Matter
About this book
Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson’s disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.
Authors and Affiliations
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Department of Biomedical Signals and Systems, University of Twente, AE Enschede, The Netherlands
Tjitske Heida, Enrico Marani
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Department of Anatomy & Histology, Medical University Sofia, Sofia, Bulgaria
Kamen G. Usunoff
Bibliographic Information
Book Title: The Subthalamic Nucleus
Book Subtitle: Part II: Modelling and Simulation of Activity
Authors: Tjitske Heida, Enrico Marani, Kamen G. Usunoff
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-540-79462-2
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008
Softcover ISBN: 978-3-540-79461-5Published: 23 July 2008
eBook ISBN: 978-3-540-79462-2Published: 20 July 2008
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: XIV, 88
Number of Illustrations: 50 b/w illustrations, 4 illustrations in colour
Topics: Neurosciences