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- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 198)
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Table of contents (6 chapters)
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Front Matter
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Back Matter
About this book
This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsukaand Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.
Authors and Affiliations
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Department of Biomedical Signals and Systems, University of Twente, AE Enschede, The Netherlands
Enrico Marani, Tjitske Heida
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Department of Neurosurgery, Leiden University Medical Centre, RC Leiden, The Netherlands
Egbert A. J. F. Lakke
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Department of Anatomy & Histology, Medical University Sofia, Sofia, Bulgaria
Kamen G. Usunoff
Bibliographic Information
Book Title: The Subthalamic Nucleus
Book Subtitle: Part I: Development, Cytology, Topography and Connections
Authors: Enrico Marani, Tjitske Heida, Egbert A. J. F. Lakke, Kamen G. Usunoff
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-540-79460-8
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008
Softcover ISBN: 978-3-540-79459-2Published: 23 July 2008
eBook ISBN: 978-3-540-79460-8Published: 19 July 2008
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: XIV, 117
Topics: Neurosciences