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Signaling Pathways for Translation

Stress, Calcium, and Rapamycin

  • Book
  • © 2001

Overview

Editors:
  1. Robert E. Rhoads

    1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, USA

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  • An up-to-date overview of the effects of stress and apoptosis on translation
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 27)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-X
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  2. The Regulation of eIF4F During Cell Growth and Cell Death

    • Simon J. Morley
    Pages 1-37

  3. Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells

    • Gert C. Scheper, Roel Van Wijk, Adri A. M. Thomas
    Pages 39-56

  4. Initiation Factor eIF2α Phosphorylation in Stress Responses and Apoptosis

    • Michael J. Clemens
    Pages 57-89

  5. Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium

    • Angus C. Nairn, Masayuki Matsushita, Kent Nastiuk, Atsuko Horiuchi, Ken-Ichi Mitsui, Yoshio Shimizu et al.
    Pages 91-129

  6. Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation

    • Malathy Mahalingam, Jonathan A. Cooper
    Pages 131-142

  7. Control of Translation by the Target of Rapamycin Proteins

    • Anne-Claude Gingras, Brian Raught, Nahum Sonenberg
    Pages 143-174

  8. Back Matter

    Pages 175-176
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Keywords

About this book

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, USA

    Robert E. Rhoads

Bibliographic Information

  • Book Title: Signaling Pathways for Translation

  • Book Subtitle: Stress, Calcium, and Rapamycin

  • Editors: Robert E. Rhoads

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-662-09889-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-41710-1Published: 17 July 2001

  • Softcover ISBN: 978-3-642-07505-6Published: 15 December 2010

  • eBook ISBN: 978-3-662-09889-9Published: 29 June 2013

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: X, 178

  • Topics: Cell Biology, Biochemistry, general

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