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Mechanism of Toxic Action on Some Target Organs

Drugs and Other Substances

  • Conference proceedings
  • © 1979

Overview

Editors:
  1. Philip L. Chambers

    1. Dept. of Pharmacology, Trinity College, Dublin 2, Ireland

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    You can also search for this editor in PubMed   Google Scholar

  2. Peter Günzel

    1. Dept. of Exp. Toxicology, Schering AG, Berlin-Bergkamen, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 2)

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Table of contents (68 papers)

  1. Front Matter

    Pages I-X
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  2. Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

    1. Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

      • J. A. Timbrell
      Pages 1-8

  3. The Influence of the Neuro-Endocrine System on the Toxic Reactions Due to Hormones and Other Compounds

    1. Front Matter

      Pages 9-9
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    2. Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man

      • M. F. El Etreby, K. J. Gräf, P. Günzel, F. Neumann
      Pages 11-39

    3. Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hormone Secretion in Oestrogen-Induced Kidney Tumours in Male Hamsters

      • P. G. Saluja, J. M. Hamilton, A. J. Thody, A. A. Ismail, J. Knowles
      Pages 41-45

    4. Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Species

      • J. Meites
      Pages 47-58

    5. Evaluation of the Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man

      • V. A. Drill
      Pages 59-84

    6. Assessment of ACTH-Adrenal Activity After Treatment with a Glucocorticoid and an Antiandrogenic Steroid

      • J. Girard, J. B. Baumann, S. Graf, G. van Hees, M. Rosenthal, K. Zuppinger
      Pages 85-92

    7. Neuroendocrine Effects of Neuropsychotropic Drugs and Their Possible Influence on Toxic Reactions in Animals and Man — The Role of the Dopamine-Prolactin System

      • R. Horowski, K.-J. Gräf
      Pages 93-104

    8. Motility and Stereotyped Behaviour Induced by Amphetamine and Apomorphine on Hypophysectomized and on Thyroidectomized Rats

      • A. Benakis
      Pages 105-109

  4. Induction of Adaptive and Malignant Liver Growth by Drugs and Environmental Pollutants

    1. Front Matter

      Pages 111-111
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    2. Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mechanism

      • R. Schulte-Hermann
      Pages 113-124

    3. Growth Control in Regenerating Rat Liver

      • K. Weinbren
      Pages 125-130

    4. Control of Liver Growth by Growth Inhibitors (Chalones)

      • C. Nadal
      Pages 131-142

    5. Nucleic Acid and Pyrimidine Nucleotide Metabolism During Liver Growth Induced by Xenobiotic Compounds

      • J. Seifert, E. Buchar
      Pages 143-144

    6. Early Biological Markers During Liver Carcinogenesis

      • P. Bannasch, H.-J. Hacker, D. Mayer
      Pages 145-155

    7. Correlation of Liver Growth and Function During Liver Regeneration and Hepatocarcinogenesis

      • H. Barbason, V. Smoliar, J. Van Cantfort
      Pages 157-169

    8. Liver Growth and Tumorigenesis in Rats

      • P. Grasso
      Pages 171-180

    9. Liver Tumors and Steroid Hormones in Rats and Mice

      • J. Schuppler, P. Günzel
      Pages 181-195

    10. The Effects of Dieldrin, Diet and Other Environmental Components on Enzyme Function and Tumour Incidence in Livers of CF-1 Mice

      • H. A. Tennekes, A. S. Wright, K. M. Dix
      Pages 197-212
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Keywords

About this book

The first oral contraceptive became available in 1960 and since then these sub­ stances, which have been used by millions of women, have probably been the most widely studied group of drugs in medical history (Drill, 1966, 1977). Part of the evaluation oCoral contraceptives has involved their effect on the reproductive organs of women, with particular attention directed to evaluation of a possible carcinogenic effect of these steroids. To the extent that cancer of the reproductive organs is a common finding in women, the endogenous female sex hormones have been implicated in the occur­ rence of the cancer. The administration of estrogen has also been reported to in­ crease the incidence of cancer of the breast, cervix or endometrium in some strains or species of animals. Thus, because of the possible tumorigenic effect of estrogens there has been considerable interest in the relationship of oral contraceptives to cancer of the breast and genital tract.

Editors and Affiliations

  • Dept. of Pharmacology, Trinity College, Dublin 2, Ireland

    Philip L. Chambers

  • Dept. of Exp. Toxicology, Schering AG, Berlin-Bergkamen, Germany

    Peter Günzel

Bibliographic Information

  • Book Title: Mechanism of Toxic Action on Some Target Organs

  • Book Subtitle: Drugs and Other Substances

  • Editors: Philip L. Chambers, Peter Günzel

  • Series Title: Archives of Toxicology

  • DOI: https://doi.org/10.1007/978-3-642-67265-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1979

  • Softcover ISBN: 978-3-540-09305-3Published: 01 May 1979

  • eBook ISBN: 978-3-642-67265-1Published: 12 March 2013

  • Series ISSN: 0171-9750

  • Edition Number: 1

  • Number of Pages: X, 534

  • Number of Illustrations: 22 b/w illustrations

  • Topics: Medicine/Public Health, general

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