Pediatric Obesity

1. Front Matter

   Pages i-xxv

   PDF

2. The Obesity Epidemic: A Global Perspective

   1. Front Matter

      Pages 1-1

      PDF

   2. Childhood Obesity in the Modern Age: Global Trends, Determinants, Complications, and Costs

      • Michael Freemark

      Pages 3-24

3. Hormonal and Metabolic Control of Appetite, Fat Deposition, and Energy Expenditure

   1. Front Matter

      Pages 25-25

      PDF

   2. Central Control of Energy Metabolism and Hypothalamic Obesity

      • Belma Haliloglu, Abdullah Bereket

      Pages 27-42

   3. Gastrointestinal Hormones and the Control of Food Intake and Energy Metabolism

      • Laura C. Page, Mark D. Miller, David D’Alessio, Jenny Tong

      Pages 43-61

   4. The Gut Microbiome and Control of Weight Gain

      • Anita L. Kozyrskyj, Hein Min Tun, Sarah L. Bridgman

      Pages 63-78

4. Adipocyte Development and Function in Obesity and Insulin Resistance

   1. Front Matter

      Pages 79-79

      PDF

   2. White Adipose Tissue Development and Function in Children and Adolescents: Preclinical Models

      • Pamela Fischer-Posovszky, Julian Roos, Verena Zoller, Martin Wabitsch

      Pages 81-93

   3. White Adipose Tissue Accumulation and Dysfunction in Children with Obesity

      • Antje Körner, Wieland Kiess, Kathrin Landgraf

      Pages 95-115

   4. Brown Adipose Tissue and Body Weight Regulation

      • Michael Freemark, Sheila Collins

      Pages 117-132

5. The Genetics of Childhood Obesity

   1. Front Matter

      Pages 133-133

      PDF

   2. Monogenic Obesity

      • Marie Pigeyre, David Meyre

      Pages 135-152

   3. Syndromic Obesity

      • Krystal A. Irizarry, Andrea M. Haqq

      Pages 153-182

   4. Polygenic Obesity

      • Anke Hinney, Johanna Giuranna

      Pages 183-202

6. Pre- and Peri-natal Determinants of Childhood Obesity

   1. Front Matter

      Pages 203-203

      PDF

   2. Maternal Determinants of Childhood Obesity: Maternal Obesity, Weight Gain and Smoking

      • Jenna Hollis, Hazel Inskip, Siân Robinson

      Pages 205-213

   3. Fetal and Infancy Growth

      • Ken K. Ong

      Pages 215-227

   4. Intrauterine Exposure to Maternal Diabetes and Childhood Obesity

      • Dana Dabelea, Katherine A. Sauder

      Pages 229-242

   5. Endocrine Disruptors as Obesogens

      • Leonardo Trasande, Bruce Blumberg

      Pages 243-253

This second edition of Freemark’s text embodies all of the strengths of the original work but is deeper and broader in scope, with new chapters on emerging themes including metabolomics, genomics, and the roles of gastrointestinal hormones, the microbiome, brown adipose tissue, and endocrine disruptors in the pathogenesis of childhood obesity. Reviews of the effects of weight excess on cognitive performance and immune function complement detailed analyses of the biochemical and molecular pathways controlling the development of childhood adiposity and metabolic disease. Critical assessments of nutritional interventions (including new chapters on infant feeding practices and vegetarian diets) and superb reviews of behavioral counseling, pharmacotherapy, and bariatric surgery provide practical guidance for the management of overweight children. Penetrating analyses of the obesity epidemic in its social, cultural, economic, and political contexts highlight challenges and opportunities forobesity prevention and community action. The perspective is international in scope and reflects the expertise and experience of many of the leading figures in the field.

Comprehensive and up-to-date, this new edition of Pediatric Obesity: Etiology, Pathogenesis and Treatment will be an invaluable guide for all healthcare providers and policy makers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.

• Adipocyte
• Gastrointestinal hormones
• Lifestyle intervention
• Metabolic complications
• Microbiome
• Monogenic obesity
• Neuroendocrine control
• Pediatric obesity
• Polygenic obesity
• Syndromic obesity
• Type 2 diabetes
• Weight gain

“There is no other book on pediatric obesity on the market that compares to this one. It covers all the basic sciences, social sciences, and clinical sciences that play a role in pediatric obesity. The most unique feature of this book is that at the end of each chapter, the author submits questions to the chapter authors. … They give the book a great human touch.” (Dyan Hes, Doody's Book Reviews, May, 2018)


“This is an analysis of the obesity epidemic in its social, cultural, economic, and political contexts. It highlights challenges and opportunities for pediatric obesity prevention and community action.  … reviews of behavioural counselling, pharmacotherapy, and bariatric surgery provide practical guidance for the management of overweight children.” (Journal of Consumer Policy, Vol. 42 (1), 2019)

• Duke University School of Medicine , Durham, USA

  Michael S. Freemark

Michael S. Freemark, MD, Robert C. and Veronica Atkins Professor of Pediatrics, Chief, Division of Pediatric Endocrinology and Diabetes, Duke University School of Medicine, Durham, NC, USA

Policies and ethics