Overview
- Provides a good overview on the role of BMPs as regulators in Systems Biology?
- Complements the first three volumes on BMPs in the series (BMPs-from laboratory to clinical practice; BMPs-regeneration of bone and beyond; BMPs-from local to systemic therapeutics)
- Adresses their role in orthopaedic and dental medicine as well as in development, cancer, PAH, chronic kidney diseases and others
Part of the book series: Progress in Inflammation Research (PIR)
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Table of contents (18 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes.
This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
Editors and Affiliations
Bibliographic Information
Book Title: Bone Morphogenetic Proteins: Systems Biology Regulators
Editors: Slobodan Vukicevic, Kuber T. Sampath
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-319-47507-3
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-47505-9Published: 23 March 2017
Softcover ISBN: 978-3-319-83753-6Published: 07 August 2018
eBook ISBN: 978-3-319-47507-3Published: 14 March 2017
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XII, 445
Number of Illustrations: 11 b/w illustrations, 32 illustrations in colour
Topics: Immunology, Cell Biology, Cytokines and Growth Factors, Protein Science, Systems Biology